In this chapter, we examine policy interventions to improve the efficiency and risk mitigation methods in an agriculture-based malaria medicine. Artemisinin combination therapy (ACT) is the most effective malaria treatment. ACT is obtained from artemisinin which is extracted from the leaves of plant called Artemisia annua. The price of artemisinin exhibited significant variations in recent years. Our study benefits donor organizations such the Global Fund to Fight AIDS, TB, and malaria and the US President’s Malaria Initiative, the World Health Organization, UNITAID, the United Kingdom Department for International Development, and the Bill and Melinda Gates Foundation in multiple ways: it helps increase the level of artemisinin production, reduce volatility of artemisinin prices, and improve access to malaria medicines for the regions in need. Using field data, our model shows that interventions aimed at improving average yield, creating a support-price for agricultural artemisinin, and carefully managing the supply of semi-synthetic artemisinin help improve the supply of artemisinin, reducing the price fluctuations in the malaria medicine.