Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: Mitotic checkpoint abrogation and NF-κB activation

H. Iha, T. Kasai, K. V. Kibler, Y. Iwanaga, K. Tsurugi, K. T. Jeang

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Tax protein expressed by human T cell leukemia virus type 1 (HTLV-1) is a strong trans-activator of its own LTR promoter; it also affects the function of multiple cellular genes involved in cell cycle control and transcription. One way in which Tax exerts its pleiotropic effects is through protein-protein interaction with cellular cofactors. By using yeast two-hybrid technology, we have isolated several cellular proteins that bind to Tax. Two of these are MAD1, a mitotic checkpoint control protein, and TXBP151, a suppressor of tumor necrosis factor α-induced apoptosis. Here we discuss findings describing the role of MAD1 in exit of cells from mitosis and TXBP151 in NF-κB activation.

Original languageEnglish (US)
Pages (from-to)1633-1638
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume16
Issue number16
DOIs
StatePublished - Nov 1 2000

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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