TY - JOUR
T1 - Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism
T2 - Mitotic checkpoint abrogation and NF-κB activation
AU - Iha, H.
AU - Kasai, T.
AU - Kibler, K. V.
AU - Iwanaga, Y.
AU - Tsurugi, K.
AU - Jeang, K. T.
PY - 2000/11/1
Y1 - 2000/11/1
N2 - Tax protein expressed by human T cell leukemia virus type 1 (HTLV-1) is a strong trans-activator of its own LTR promoter; it also affects the function of multiple cellular genes involved in cell cycle control and transcription. One way in which Tax exerts its pleiotropic effects is through protein-protein interaction with cellular cofactors. By using yeast two-hybrid technology, we have isolated several cellular proteins that bind to Tax. Two of these are MAD1, a mitotic checkpoint control protein, and TXBP151, a suppressor of tumor necrosis factor α-induced apoptosis. Here we discuss findings describing the role of MAD1 in exit of cells from mitosis and TXBP151 in NF-κB activation.
AB - Tax protein expressed by human T cell leukemia virus type 1 (HTLV-1) is a strong trans-activator of its own LTR promoter; it also affects the function of multiple cellular genes involved in cell cycle control and transcription. One way in which Tax exerts its pleiotropic effects is through protein-protein interaction with cellular cofactors. By using yeast two-hybrid technology, we have isolated several cellular proteins that bind to Tax. Two of these are MAD1, a mitotic checkpoint control protein, and TXBP151, a suppressor of tumor necrosis factor α-induced apoptosis. Here we discuss findings describing the role of MAD1 in exit of cells from mitosis and TXBP151 in NF-κB activation.
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U2 - 10.1089/08892220050193074
DO - 10.1089/08892220050193074
M3 - Article
C2 - 11080803
AN - SCOPUS:0034330846
SN - 0889-2229
VL - 16
SP - 1633
EP - 1638
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 16
ER -