Plasmodium vivax populations revisited

Mitochondrial genomes of temperate strains in Asia suggest ancient population expansion

Miao Miao, Zhaoqing Yang, Harland Patch, Yaming Huang, Ananias A. Escalante, Liwang Cui

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Plasmodium vivax is the most widely distributed human malaria parasite outside of Africa, and its range extends well into the temperate zones. Previous studies provided evidence for vivax population differentiation, but temperate vivax parasites were not well represented in these analyses. Here we address this deficit by using complete mitochondrial (mt) genome sequences to elucidate the broad genetic diversity and population structure of P. vivax from temperate regions in East and Southeast Asia. Results: From the complete mtDNA sequences of 99 clinical samples collected in China, Myanmar and Korea, a total of 30 different haplotypes were identified from 26 polymorphic sites. Significant differentiation between different East and Southeast Asian parasite populations was observed except for the comparison between populations from Korea and southern China. Haplotype patterns and structure diversity analysis showed coexistence of two different groups in East Asia, which were genetically related to the Southeast Asian population and Myanmar population, respectively. The demographic history of P. vivax, examined using neutrality tests and mismatch distribution analyses, revealed population expansion events across the entire P. vivax range and the Myanmar population. Bayesian skyline analysis further supported the occurrence of ancient P. vivax population expansion. Conclusions: This study provided further resolution of the population structure and evolution of P. vivax, especially in temperate/warm-temperate endemic areas of Asia. The results revealed divergence of the P. vivax populations in temperate regions of China and Korea from other populations. Multiple analyses confirmed ancient population expansion of this parasite. The extensive genetic diversity of the P. vivax populations is consistent with phenotypic plasticity of the parasites, which has implications for malaria control.

Original languageEnglish (US)
Article number22
JournalBMC Evolutionary Biology
Volume12
Issue number1
DOIs
StatePublished - 2012

Fingerprint

Plasmodium vivax
parasite
genome
malaria
population structure
Myanmar
parasites
demographic history
Korean Peninsula
phenotypic plasticity
coexistence
East Asia
divergence
China
mitochondrial genome
Asia
haplotypes
genetic variation
Bayesian theory
temperate zones

Keywords

  • biogeography
  • genetic diversity
  • mitochondrial DNA
  • Plasmodium vivax

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Plasmodium vivax populations revisited : Mitochondrial genomes of temperate strains in Asia suggest ancient population expansion. / Miao, Miao; Yang, Zhaoqing; Patch, Harland; Huang, Yaming; Escalante, Ananias A.; Cui, Liwang.

In: BMC Evolutionary Biology, Vol. 12, No. 1, 22, 2012.

Research output: Contribution to journalArticle

Miao, Miao ; Yang, Zhaoqing ; Patch, Harland ; Huang, Yaming ; Escalante, Ananias A. ; Cui, Liwang. / Plasmodium vivax populations revisited : Mitochondrial genomes of temperate strains in Asia suggest ancient population expansion. In: BMC Evolutionary Biology. 2012 ; Vol. 12, No. 1.
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abstract = "Background: Plasmodium vivax is the most widely distributed human malaria parasite outside of Africa, and its range extends well into the temperate zones. Previous studies provided evidence for vivax population differentiation, but temperate vivax parasites were not well represented in these analyses. Here we address this deficit by using complete mitochondrial (mt) genome sequences to elucidate the broad genetic diversity and population structure of P. vivax from temperate regions in East and Southeast Asia. Results: From the complete mtDNA sequences of 99 clinical samples collected in China, Myanmar and Korea, a total of 30 different haplotypes were identified from 26 polymorphic sites. Significant differentiation between different East and Southeast Asian parasite populations was observed except for the comparison between populations from Korea and southern China. Haplotype patterns and structure diversity analysis showed coexistence of two different groups in East Asia, which were genetically related to the Southeast Asian population and Myanmar population, respectively. The demographic history of P. vivax, examined using neutrality tests and mismatch distribution analyses, revealed population expansion events across the entire P. vivax range and the Myanmar population. Bayesian skyline analysis further supported the occurrence of ancient P. vivax population expansion. Conclusions: This study provided further resolution of the population structure and evolution of P. vivax, especially in temperate/warm-temperate endemic areas of Asia. The results revealed divergence of the P. vivax populations in temperate regions of China and Korea from other populations. Multiple analyses confirmed ancient population expansion of this parasite. The extensive genetic diversity of the P. vivax populations is consistent with phenotypic plasticity of the parasites, which has implications for malaria control.",
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