@article{ff34e8ffdd594a5aa26289d077671bc0,
title = "Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade",
abstract = "P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax.",
author = "Tachibana, {Shin Ichiro} and Sullivan, {Steven A.} and Satoru Kawai and Shota Nakamura and Kim, {Hyunjae R.} and Naohisa Goto and Nobuko Arisue and Palacpac, {Nirianne M Q} and Hajime Honma and Masanori Yagi and Takahiro Tougan and Yuko Katakai and Osamu Kaneko and Toshihiro Mita and Kiyoshi Kita and Yasuhiro Yasutomi and Sutton, {Patrick L.} and Rimma Shakhbatyan and Toshihiro Horii and Teruo Yasunaga and Barnwell, {John W.} and Escalante, {Ananias A.} and Carlton, {Jane M.} and Kazuyuki Tanabe",
note = "Funding Information: We thank H. Sawai for suggestions on genome analysis, D. Fisher for help with genome-wide evolutionary analyses and the NYU Langone Medical Center Genome Technology Core for access to Roche 454 sequencing equipment (funded by grant S10 RR026950 to J.M.C. from the US National Institutes of Health (NIH)). Genome and phylogenetic analyses used the Genome Information Research Center in the Research Institute of Microbial Diseases at Osaka University. This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (18073013, 18GS03140013, 20390120 and 22406012) to K.T., an NIH grant (R01 GM080586) to A.A.E. and a Burroughs Wellcome Fund grant (1007398) and an NIH International Centers of Excellence for Malaria Research grant (U19 AI089676-01) to J.M.C. The content is soley the responsibility of the authors and does not necessarily represent the official views of the NIH.",
year = "2012",
month = sep,
doi = "10.1038/ng.2375",
language = "English (US)",
volume = "44",
pages = "1051--1055",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",
}