Plasma-based fast-gelling biohybrid gels for biomedical applications

Amrita Pal, Kunal Tripathi, Chandrashekhar Pathak, Brent Vernon

Research output: Contribution to journalArticle

Abstract

Blood based biomaterials are widely researched and used in different biomedical applications including cell therapy, drug delivery, sealants etc. due to their biocompatibility and biodegradability. Blood derived gels are successfully used in clinical studies due to the presence of fibrinogen and several platelet growth factors. In spite of their wide applications, it is challenging to use blood-based biomaterials due to their low mechanical stability, poor adhesive property and contamination risk. In this study, we used porcine plasma to form gel in presence of biodegradable synthetic crosslinkers. Mechanical strength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired biomedical applications. These plasma gels, formed by the synthetic crosslinkers, were utilized as a drug delivery platform for wound healing due to their low cytotoxicity. A model drug release study with these plasma gels indicated slow and sustained release of the drugs.

Original languageEnglish (US)
Article number10881
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Fingerprint

Gels
Plasmas
Blood
Biocompatible Materials
Drug delivery
Sealants
Mechanical stability
Biodegradability
Cytotoxicity
Platelets
Biocompatibility
Pharmaceutical Preparations
Fibrinogen
Strength of materials
Adhesives
Intercellular Signaling Peptides and Proteins
Contamination

ASJC Scopus subject areas

  • General

Cite this

Plasma-based fast-gelling biohybrid gels for biomedical applications. / Pal, Amrita; Tripathi, Kunal; Pathak, Chandrashekhar; Vernon, Brent.

In: Scientific reports, Vol. 9, No. 1, 10881, 01.12.2019.

Research output: Contribution to journalArticle

Pal, Amrita ; Tripathi, Kunal ; Pathak, Chandrashekhar ; Vernon, Brent. / Plasma-based fast-gelling biohybrid gels for biomedical applications. In: Scientific reports. 2019 ; Vol. 9, No. 1.
@article{2dd74a78fefe4529a14c81b5d561ba79,
title = "Plasma-based fast-gelling biohybrid gels for biomedical applications",
abstract = "Blood based biomaterials are widely researched and used in different biomedical applications including cell therapy, drug delivery, sealants etc. due to their biocompatibility and biodegradability. Blood derived gels are successfully used in clinical studies due to the presence of fibrinogen and several platelet growth factors. In spite of their wide applications, it is challenging to use blood-based biomaterials due to their low mechanical stability, poor adhesive property and contamination risk. In this study, we used porcine plasma to form gel in presence of biodegradable synthetic crosslinkers. Mechanical strength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired biomedical applications. These plasma gels, formed by the synthetic crosslinkers, were utilized as a drug delivery platform for wound healing due to their low cytotoxicity. A model drug release study with these plasma gels indicated slow and sustained release of the drugs.",
author = "Amrita Pal and Kunal Tripathi and Chandrashekhar Pathak and Brent Vernon",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-47366-3",
language = "English (US)",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Plasma-based fast-gelling biohybrid gels for biomedical applications

AU - Pal, Amrita

AU - Tripathi, Kunal

AU - Pathak, Chandrashekhar

AU - Vernon, Brent

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Blood based biomaterials are widely researched and used in different biomedical applications including cell therapy, drug delivery, sealants etc. due to their biocompatibility and biodegradability. Blood derived gels are successfully used in clinical studies due to the presence of fibrinogen and several platelet growth factors. In spite of their wide applications, it is challenging to use blood-based biomaterials due to their low mechanical stability, poor adhesive property and contamination risk. In this study, we used porcine plasma to form gel in presence of biodegradable synthetic crosslinkers. Mechanical strength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired biomedical applications. These plasma gels, formed by the synthetic crosslinkers, were utilized as a drug delivery platform for wound healing due to their low cytotoxicity. A model drug release study with these plasma gels indicated slow and sustained release of the drugs.

AB - Blood based biomaterials are widely researched and used in different biomedical applications including cell therapy, drug delivery, sealants etc. due to their biocompatibility and biodegradability. Blood derived gels are successfully used in clinical studies due to the presence of fibrinogen and several platelet growth factors. In spite of their wide applications, it is challenging to use blood-based biomaterials due to their low mechanical stability, poor adhesive property and contamination risk. In this study, we used porcine plasma to form gel in presence of biodegradable synthetic crosslinkers. Mechanical strength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired biomedical applications. These plasma gels, formed by the synthetic crosslinkers, were utilized as a drug delivery platform for wound healing due to their low cytotoxicity. A model drug release study with these plasma gels indicated slow and sustained release of the drugs.

UR - http://www.scopus.com/inward/record.url?scp=85069628658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069628658&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-47366-3

DO - 10.1038/s41598-019-47366-3

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 10881

ER -