Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women

Fahim Abbasi, Cindy Lamendola, Tracey McLaughlin, John Hayden, Gerald M. Reaven, Peter D. Reaven

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P < .001) and adiponectin concentrations somewhat lower (P = .10) in the IR group (P < .001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P < .001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume53
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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