TY - JOUR
T1 - Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women
AU - Abbasi, Fahim
AU - Lamendola, Cindy
AU - McLaughlin, Tracey
AU - Hayden, John
AU - Reaven, Gerald M.
AU - Reaven, Peter D.
PY - 2004/3
Y1 - 2004/3
N2 - Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P < .001) and adiponectin concentrations somewhat lower (P = .10) in the IR group (P < .001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P < .001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations.
AB - Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P < .001) and adiponectin concentrations somewhat lower (P = .10) in the IR group (P < .001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P < .001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations.
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U2 - 10.1016/j.metabol.2003.10.004
DO - 10.1016/j.metabol.2003.10.004
M3 - Article
C2 - 15015137
AN - SCOPUS:2542469639
SN - 0026-0495
VL - 53
SP - 280
EP - 283
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -