Plant cell factories and mucosal vaccines

Amanda M. Walmsley, Charles J. Arntzen

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown to protect against challenge in the target host. Increased antigen expression levels (up to 4.1% total soluble protein) have been obtained through transformation of the chloroplast genome. In view of these findings, plant-derived vaccines have been proved as valuable commodities to the world's health system; however, before their application, studies need to focus on optimization of immunization strategies and to investigate antigen stability.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume14
Issue number2
DOIs
StatePublished - Apr 2003

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Vaccines
Plant Cells
Industrial plants
Immunization
Antigens
Chloroplast Genome
Passive Immunization
T-Lymphocyte Subsets
Genes
Health
Proteins

ASJC Scopus subject areas

  • Biotechnology

Cite this

Plant cell factories and mucosal vaccines. / Walmsley, Amanda M.; Arntzen, Charles J.

In: Current Opinion in Biotechnology, Vol. 14, No. 2, 04.2003, p. 145-150.

Research output: Contribution to journalArticle

Walmsley, Amanda M. ; Arntzen, Charles J. / Plant cell factories and mucosal vaccines. In: Current Opinion in Biotechnology. 2003 ; Vol. 14, No. 2. pp. 145-150.
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