Physical principles of quantitative nuclear magnetic resonance oximetry

Vikram Kodibagkar, Xianghui Wang, Ralph P. Mason

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Over the years many techniques have been devised for the measurement of tissue oxygenation (oximetry). Oximetry using polarographic needle electrodes has long been considered a gold standard. Nuclear Magnetic Resonance (NMR) based oximetry uses exogenously administered reporter molecules such as perfluorocarbons to quantitatively interrogate oxygen tension (pO2). This technique has been successfully used in vivo in the preclinical setting and shows promise for clinical applications. NMR pO2 reporter molecules display a linear dependence of the spin lattice relaxation rate on pO 2, which forms the basis of this technique. Physical principles of spin lattice relaxation of pO2 reporter molecules and the pO 2 dependence of relaxation rate are discussed in this review. Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described.

Original languageEnglish (US)
Pages (from-to)1371-1384
Number of pages14
JournalFrontiers in Bioscience
Volume13
Issue number4
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Oximetry
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Molecules
Spin-lattice relaxation
Fluorocarbons
Needles
Oxygenation
Electrodes
Oxygen
Tissue

Keywords

  • F
  • Hexamethyldisiloxane
  • Hypoxia
  • MRI
  • Oximetry
  • Perfluorocarbons
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Medicine(all)

Cite this

Physical principles of quantitative nuclear magnetic resonance oximetry. / Kodibagkar, Vikram; Wang, Xianghui; Mason, Ralph P.

In: Frontiers in Bioscience, Vol. 13, No. 4, 2008, p. 1371-1384.

Research output: Contribution to journalArticle

Kodibagkar, Vikram ; Wang, Xianghui ; Mason, Ralph P. / Physical principles of quantitative nuclear magnetic resonance oximetry. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 4. pp. 1371-1384.
@article{f31ad33d2a054c018e163e6b711868b3,
title = "Physical principles of quantitative nuclear magnetic resonance oximetry",
abstract = "Over the years many techniques have been devised for the measurement of tissue oxygenation (oximetry). Oximetry using polarographic needle electrodes has long been considered a gold standard. Nuclear Magnetic Resonance (NMR) based oximetry uses exogenously administered reporter molecules such as perfluorocarbons to quantitatively interrogate oxygen tension (pO2). This technique has been successfully used in vivo in the preclinical setting and shows promise for clinical applications. NMR pO2 reporter molecules display a linear dependence of the spin lattice relaxation rate on pO 2, which forms the basis of this technique. Physical principles of spin lattice relaxation of pO2 reporter molecules and the pO 2 dependence of relaxation rate are discussed in this review. Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described.",
keywords = "F, Hexamethyldisiloxane, Hypoxia, MRI, Oximetry, Perfluorocarbons, Review",
author = "Vikram Kodibagkar and Xianghui Wang and Mason, {Ralph P.}",
year = "2008",
doi = "10.2741/2768",
language = "English (US)",
volume = "13",
pages = "1371--1384",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "4",

}

TY - JOUR

T1 - Physical principles of quantitative nuclear magnetic resonance oximetry

AU - Kodibagkar, Vikram

AU - Wang, Xianghui

AU - Mason, Ralph P.

PY - 2008

Y1 - 2008

N2 - Over the years many techniques have been devised for the measurement of tissue oxygenation (oximetry). Oximetry using polarographic needle electrodes has long been considered a gold standard. Nuclear Magnetic Resonance (NMR) based oximetry uses exogenously administered reporter molecules such as perfluorocarbons to quantitatively interrogate oxygen tension (pO2). This technique has been successfully used in vivo in the preclinical setting and shows promise for clinical applications. NMR pO2 reporter molecules display a linear dependence of the spin lattice relaxation rate on pO 2, which forms the basis of this technique. Physical principles of spin lattice relaxation of pO2 reporter molecules and the pO 2 dependence of relaxation rate are discussed in this review. Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described.

AB - Over the years many techniques have been devised for the measurement of tissue oxygenation (oximetry). Oximetry using polarographic needle electrodes has long been considered a gold standard. Nuclear Magnetic Resonance (NMR) based oximetry uses exogenously administered reporter molecules such as perfluorocarbons to quantitatively interrogate oxygen tension (pO2). This technique has been successfully used in vivo in the preclinical setting and shows promise for clinical applications. NMR pO2 reporter molecules display a linear dependence of the spin lattice relaxation rate on pO 2, which forms the basis of this technique. Physical principles of spin lattice relaxation of pO2 reporter molecules and the pO 2 dependence of relaxation rate are discussed in this review. Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described.

KW - F

KW - Hexamethyldisiloxane

KW - Hypoxia

KW - MRI

KW - Oximetry

KW - Perfluorocarbons

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=38449092059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449092059&partnerID=8YFLogxK

U2 - 10.2741/2768

DO - 10.2741/2768

M3 - Article

VL - 13

SP - 1371

EP - 1384

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 4

ER -