TY - JOUR
T1 - Physical performance and movement-evoked pain profiles in community-dwelling individuals at risk for knee osteoarthritis
AU - Cruz-Almeida, Yenisel
AU - Cardoso, Josue
AU - Riley, Joseph L.
AU - Goodin, Burel
AU - King, Christopher D.
AU - Petrov, Megan
AU - Bartley, Emily J.
AU - Sibille, Kimberly T.
AU - Glover, Toni L.
AU - Herbert, Matthew S.
AU - Bulls, Hailey W.
AU - Addison, Adriana
AU - Staud, Roland
AU - Redden, David
AU - Bradley, Laurence A.
AU - Fillingim, Roger B.
N1 - Funding Information:
The current study was supported by the National Institutes of Health/National Institute on Aging ( R37AG033906 ), the University of Florida Clinical and Translational Science Institute ( UL1TR000064 ), and the University of Alabama at Birmingham Center for Clinical and Translational Science Institute ( UL1TR000165 ). YC-A is funded by the National Institute on Aging, K01AG048259; KTS is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, K23AR062099; CK by the National Institute on Dental and Craniofacial Research, K99DE022368; and EJB by the NIA K99AG052642. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/11
Y1 - 2017/11
N2 - Background Knee pain associated with osteoarthritis is a significant contributor to decreased physical function. Recent evidence supports the inter-individual heterogeneity associated with knee pain presentation, but whether there is similar heterogeneity in physical performance among these individuals has not been previously examined. The aim of the present study was to characterize the variability in physical performance profiles and the pain evoked by their performance (i.e., movement-evoked pain). Methods In a secondary analysis of the community-based study Understanding Pain and Limitations in Osteoarthritic Disease (UPLOAD), individuals (n = 270) completed functional, pain, psychological, and somatosensory assessments. Hierarchical cluster analysis was used to derive physical function profiles that were subsequently compared across several clinical, psychological and experimental pain measures. Results Our results support the hypothesis that among persons with knee OA pain, three different physical performance profiles exist with varying degrees of movement-evoked pain. Even as all three groups experienced moderate to severe levels of spontaneous knee pain, those individuals with the most severe movement-evoked pain and lowest physical functional performance also had the least favorable psychological characteristics along with increased mechanical pain sensitivity and temporal summation. Conclusions Our findings support the need for the assessment and consideration of movement-evoked pain during physical performance tasks as these have the potential to increase the value of functional and pain assessments clinically. The identification of the mechanisms driving pain burden within homogeneous groups of individuals will ultimately allow for targeted implementation of treatments consistent with a biopsychosocial model of pain.
AB - Background Knee pain associated with osteoarthritis is a significant contributor to decreased physical function. Recent evidence supports the inter-individual heterogeneity associated with knee pain presentation, but whether there is similar heterogeneity in physical performance among these individuals has not been previously examined. The aim of the present study was to characterize the variability in physical performance profiles and the pain evoked by their performance (i.e., movement-evoked pain). Methods In a secondary analysis of the community-based study Understanding Pain and Limitations in Osteoarthritic Disease (UPLOAD), individuals (n = 270) completed functional, pain, psychological, and somatosensory assessments. Hierarchical cluster analysis was used to derive physical function profiles that were subsequently compared across several clinical, psychological and experimental pain measures. Results Our results support the hypothesis that among persons with knee OA pain, three different physical performance profiles exist with varying degrees of movement-evoked pain. Even as all three groups experienced moderate to severe levels of spontaneous knee pain, those individuals with the most severe movement-evoked pain and lowest physical functional performance also had the least favorable psychological characteristics along with increased mechanical pain sensitivity and temporal summation. Conclusions Our findings support the need for the assessment and consideration of movement-evoked pain during physical performance tasks as these have the potential to increase the value of functional and pain assessments clinically. The identification of the mechanisms driving pain burden within homogeneous groups of individuals will ultimately allow for targeted implementation of treatments consistent with a biopsychosocial model of pain.
KW - Inter-individual variability
KW - Pain
KW - Physical function
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U2 - 10.1016/j.exger.2017.08.026
DO - 10.1016/j.exger.2017.08.026
M3 - Article
C2 - 28842222
AN - SCOPUS:85028990274
SN - 0531-5565
VL - 98
SP - 186
EP - 191
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -