TY - JOUR
T1 - Physical bioenergetics
T2 - Energy fluxes, budgets, and constraints in cells
AU - Yang, Xingbo
AU - Heinemann, Matthias
AU - Howard, Jonathon
AU - Huber, Greg
AU - Iyer-Biswas, Srividya
AU - Le Treut, Guillaume
AU - Lynch, Michael
AU - Montooth, Kristi L.
AU - Needleman, Daniel J.
AU - Pigolotti, Simone
AU - Rodenfels, Jonathan
AU - Ronceray, Pierre
AU - Shankar, Sadasivan
AU - Tavassoly, Iman
AU - Thutupalli, Shashi
AU - Titov, Denis V.
AU - Wang, Jin
AU - Foster, Peter J.
N1 - Funding Information:
We thank Yuhai Tu for helpful suggestions. This paper was inspired in part by the Cellular Energetics program at the Kavli Institute for Theoretical Physics, and we acknowledge all the insightful discussions among the participants (for details, see https://www.kitp.ucsb.edu/activities/cellenergy19). This research was supported in part by NSF grant NSF PHY-1748958, NIH grant R25GM067110, and Gordon and Betty Moore Foundation grant 2919.02. P.J.F. acknowledges support from the Gordon and Betty Moore Foundation for support as a Physics of Living Systems Fellow through grant GBMF4513. J.W. was supported by NSF-PHY-76066, NSF-DMS-1951385, CHE-1808474, and NIH grants R01GM124177 and 1UF1NS115779-01. D.J.N. was supported by NSF grants PHY2013874, MCB2052305, DMR1420570, and DMR2004380 and NIH grant R01HD092550-01. D.V.T. was supported by DP2 GM132933. G.H. and G.L.T. acknowledge support from the Chan Zuckerberg Biohub. J.H. was supported by NIH grants DP1 MH110065 and R01 GM110386. J.R. was supported by European Molecular Biology Organization grant ALTF 754-2015 and NIH grant R21 HD094013 (to Karla M. Neugebauer). P.R. is supported by the NSF through the Center for the Physics of Biological Function (PHY-1734030), by the French National Research Agency (ANR-16-CONV-0001), and by the Excellence Initiative of Aix-Marseille University—A*MIDEX. S.T. acknowledges support from the Simons Foundation (grant 287975) and the Max Planck Society via a Partner Group. S.P. acknowledges support by Japan Society for the Promotion of Science KAKENHI grant JP18K03473. M.L. acknowledges support by US Department of Army through MURI award W911NF-14-1-0411, NIH grant R35-GM122566-01, NSF grant DEB-1927159, and Moore and Simons Foundations grant 735927. Figures were created with http://BioRender.com.
Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.
PY - 2021/6/29
Y1 - 2021/6/29
N2 - Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.
AB - Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.
KW - Energetic constraints
KW - Energetic costs
KW - Energy fluxes
KW - Physical bioenergetics
UR - http://www.scopus.com/inward/record.url?scp=85108312527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108312527&partnerID=8YFLogxK
U2 - 10.1073/pnas.2026786118
DO - 10.1073/pnas.2026786118
M3 - Review article
C2 - 34140336
AN - SCOPUS:85108312527
SN - 0027-8424
VL - 118
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 26
M1 - e2026786118
ER -