Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

Xingbo Yang, Matthias Heinemann, Jonathon Howard, Greg Huber, Srividya Iyer-Biswas, Guillaume Le Treut, Michael Lynch, Kristi L. Montooth, Daniel J. Needleman, Simone Pigolotti, Jonathan Rodenfels, Pierre Ronceray, Sadasivan Shankar, Iman Tavassoly, Shashi Thutupalli, Denis V. Titov, Jin Wang, Peter J. Foster

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.

Original languageEnglish (US)
Article numbere2026786118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number26
DOIs
StatePublished - Jun 29 2021
Externally publishedYes

Keywords

  • Energetic constraints
  • Energetic costs
  • Energy fluxes
  • Physical bioenergetics

ASJC Scopus subject areas

  • General

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