Physical activity, sedentary behavior, and vitamin D metabolites

Elizabeth A. Hibler, Christine L. Sardo Molmenti, Qi Dai, Lindsay N. Kohler, Shaneda Warren Anderson, Peter Jurutka, Elizabeth T. Jacobs

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Physical activity is associated with circulating 25-hydroxyvitamin D (25(OH)D). However, the influence of activity and/or sedentary behavior on the biologically active, seco-steroid hormone 1α,25-dihydroxyvitamin D (1,25(OH)2D) is unknown. We conducted a cross-sectional analysis among ursodeoxycholic acid (UDCA) randomized trial participants (n=876) to evaluate associations between physical activity, sedentary behavior, and circulating vitamin D metabolite concentrations. Continuous vitamin D metabolite measurements and clinical thresholds were evaluated using multiple linear and logistic regression models, mutually adjusted for either 1,25(OH)2D or 25(OH)D and additional confounding factors. A statistically significant linear association between 1,25(OH)2D and moderate-vigorous physical activity per week was strongest among women (β (95% CI): 3.10 (1.51-6.35)) versus men (β (95% CI): 1.35 (0.79-2.29)) in the highest tertile of activity compared to the lowest (p-interaction=0.003). Furthermore, 25(OH)D was 1.54ng/ml (95% CI 1.09-1.98) higher per hour increase in moderate-vigorous activity (p=0.001) and odds of sufficient 25(OH)D status was higher among physically active participants (p=0.001). Sedentary behavior was not significantly associated with either metabolite in linear regression models, nor was a statistically significant interaction by sex identified. The current study identified novel associations between physical activity and serum 1,25(OH)2D levels, adjusted for 25(OH)D concentrations. These results identify the biologically active form of vitamin D as a potential physiologic mechanism related to observed population-level associations between moderate-vigorous physical activity with bone health and chronic disease risk. However, future longitudinal studies are needed to further evaluate the role of physical activity and vitamin D metabolites in chronic disease prevention.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalBone
Volume83
DOIs
StatePublished - Feb 1 2016

Fingerprint

Vitamin D
Exercise
Linear Models
Chronic Disease
Logistic Models
Ursodeoxycholic Acid
Bone Diseases
Longitudinal Studies
Cross-Sectional Studies
Steroids
Hormones
Health
Serum
Population

Keywords

  • 1α,25-dihydoxyvitamin D
  • 25-hydroxyvitamin D
  • Physical activity
  • Sedentary behavior
  • Vitamin D

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Hibler, E. A., Sardo Molmenti, C. L., Dai, Q., Kohler, L. N., Warren Anderson, S., Jurutka, P., & Jacobs, E. T. (2016). Physical activity, sedentary behavior, and vitamin D metabolites. Bone, 83, 248-255. https://doi.org/10.1016/j.bone.2015.11.016

Physical activity, sedentary behavior, and vitamin D metabolites. / Hibler, Elizabeth A.; Sardo Molmenti, Christine L.; Dai, Qi; Kohler, Lindsay N.; Warren Anderson, Shaneda; Jurutka, Peter; Jacobs, Elizabeth T.

In: Bone, Vol. 83, 01.02.2016, p. 248-255.

Research output: Contribution to journalArticle

Hibler, EA, Sardo Molmenti, CL, Dai, Q, Kohler, LN, Warren Anderson, S, Jurutka, P & Jacobs, ET 2016, 'Physical activity, sedentary behavior, and vitamin D metabolites', Bone, vol. 83, pp. 248-255. https://doi.org/10.1016/j.bone.2015.11.016
Hibler EA, Sardo Molmenti CL, Dai Q, Kohler LN, Warren Anderson S, Jurutka P et al. Physical activity, sedentary behavior, and vitamin D metabolites. Bone. 2016 Feb 1;83:248-255. https://doi.org/10.1016/j.bone.2015.11.016
Hibler, Elizabeth A. ; Sardo Molmenti, Christine L. ; Dai, Qi ; Kohler, Lindsay N. ; Warren Anderson, Shaneda ; Jurutka, Peter ; Jacobs, Elizabeth T. / Physical activity, sedentary behavior, and vitamin D metabolites. In: Bone. 2016 ; Vol. 83. pp. 248-255.
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