Physical Activity as a Nonpharmacological Symptom Management Approach in Myeloproliferative Neoplasms

Recommendations for Future Research

Ryan Eckert, Jennifer Huberty, Krisstina Gowin, Ruben Mesa, Lisa Marks

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Purpose: Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant symptom burden (eg, fatigue, depressive symptoms, early satiety) and an impaired overall quality of life (QoL). Current treatments typically include pharmacological approaches, which may come with additional side effects and may be limited by treatment-associated toxicities (ie, cytopenias). Nonpharmacological approaches such as physical activity may be beneficial for reducing symptom burden and improving QoL. To date, no studies have examined physical activity as a nonpharmacological approach in MPN patients despite preliminary evidence supporting its benefit in other hematological cancers. The purpose of this article is to (1) review the literature related to physical activity and specific hematological cancer subtypes and to (2) make suggestions for future research involving physical activity in MPN patients as a symptom management strategy. Methods: A brief review of studies examining physical activity in leukemias, lymphomas, and myelomas (excluding stem-cell transplant patients) was conducted. Results: There is preliminary evidence to suggest that physical activity may be an effective approach to improve patient-reported outcomes (fatigue, depression, anxiety, sleep), physical fitness (cardiovascular fitness, balance, body composition), and overall QoL in other hematological cancers. Conclusions: Based on encouraging findings in other hematological cancers, future research should examine the feasibility and effectiveness of physical activity in MPN patients.

Original languageEnglish (US)
Pages (from-to)439-450
Number of pages12
JournalIntegrative Cancer Therapies
Volume16
Issue number4
DOIs
StatePublished - Dec 1 2017

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Exercise
Neoplasms
Quality of Life
Fatigue
Depression
Essential Thrombocythemia
Polycythemia Vera
Primary Myelofibrosis
Physical Fitness
Splenomegaly
Hematologic Neoplasms
Myeloid Cells
Body Composition
Lymphoma
Sleep
Leukemia
Stem Cells
Anxiety
Pharmacology
Transplants

Keywords

  • aerobic
  • cancer
  • exercise
  • health promotion
  • quality of life
  • resistance

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine

Cite this

Physical Activity as a Nonpharmacological Symptom Management Approach in Myeloproliferative Neoplasms : Recommendations for Future Research. / Eckert, Ryan; Huberty, Jennifer; Gowin, Krisstina; Mesa, Ruben; Marks, Lisa.

In: Integrative Cancer Therapies, Vol. 16, No. 4, 01.12.2017, p. 439-450.

Research output: Contribution to journalReview article

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