Physical activity and exercise during preoperative pancreatic cancer treatment

Nathan H. Parker, An Ngo-Huang, Rebecca Lee, Daniel P. O’Connor, Karen M. Basen-Engquist, Maria Q.B. Petzel, Xuemei Wang, Lianchun Xiao, David R. Fogelman, Keri L. Schadler, Richard J. Simpson, Jason B. Fleming, Jeffrey E. Lee, Gauri R. Varadhachary, Sunil K. Sahai, Matthew H.G. Katz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Abstract: Purpose: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. Methods: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence. Self-reported aerobic and strengthening exercise minutes were measured using daily logs, and physical activity was measured objectively using accelerometers. Results: Fifty participants (48% female, mean age 66 ± 8 years) participated for an average of 16 ± 9 preoperative weeks. Participants reported overall means of 126 ± 83 weekly minutes of aerobic exercise and 39 ± 33 weekly minutes of strengthening exercise in daily logs. Participants performed 158.7 ± 146.7 weekly minutes of accelerometer-measured moderate-to-vigorous physical activity. There were no significant differences in exercise or physical activity between treatment phases. Conclusions: These findings suggest that it is feasible to target the entire preoperative course for exercise prescription. Although participants exceeded aerobic exercise recommendations on average, we observed low strengthening exercise adherence and wide variability in self-reported exercise and accelerometer physical activity variables. These findings suggest that additional support, including program adaptations, may be necessary to overcome barriers to exercise or improve motivation when prescribing exercise in this clinical scenario.

Original languageEnglish (US)
JournalSupportive Care in Cancer
DOIs
StateAccepted/In press - Jan 1 2018

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Pancreatic Neoplasms
Exercise
Therapeutics

Keywords

  • Accelerometer
  • Aerobic exercise
  • Cancer survivorship
  • Prehabilitation
  • Strengthening exercise
  • Surgery

ASJC Scopus subject areas

  • Oncology

Cite this

Parker, N. H., Ngo-Huang, A., Lee, R., O’Connor, D. P., Basen-Engquist, K. M., Petzel, M. Q. B., ... Katz, M. H. G. (Accepted/In press). Physical activity and exercise during preoperative pancreatic cancer treatment. Supportive Care in Cancer. https://doi.org/10.1007/s00520-018-4493-6

Physical activity and exercise during preoperative pancreatic cancer treatment. / Parker, Nathan H.; Ngo-Huang, An; Lee, Rebecca; O’Connor, Daniel P.; Basen-Engquist, Karen M.; Petzel, Maria Q.B.; Wang, Xuemei; Xiao, Lianchun; Fogelman, David R.; Schadler, Keri L.; Simpson, Richard J.; Fleming, Jason B.; Lee, Jeffrey E.; Varadhachary, Gauri R.; Sahai, Sunil K.; Katz, Matthew H.G.

In: Supportive Care in Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Parker, NH, Ngo-Huang, A, Lee, R, O’Connor, DP, Basen-Engquist, KM, Petzel, MQB, Wang, X, Xiao, L, Fogelman, DR, Schadler, KL, Simpson, RJ, Fleming, JB, Lee, JE, Varadhachary, GR, Sahai, SK & Katz, MHG 2018, 'Physical activity and exercise during preoperative pancreatic cancer treatment', Supportive Care in Cancer. https://doi.org/10.1007/s00520-018-4493-6
Parker, Nathan H. ; Ngo-Huang, An ; Lee, Rebecca ; O’Connor, Daniel P. ; Basen-Engquist, Karen M. ; Petzel, Maria Q.B. ; Wang, Xuemei ; Xiao, Lianchun ; Fogelman, David R. ; Schadler, Keri L. ; Simpson, Richard J. ; Fleming, Jason B. ; Lee, Jeffrey E. ; Varadhachary, Gauri R. ; Sahai, Sunil K. ; Katz, Matthew H.G. / Physical activity and exercise during preoperative pancreatic cancer treatment. In: Supportive Care in Cancer. 2018.
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abstract = "Abstract: Purpose: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. Methods: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence. Self-reported aerobic and strengthening exercise minutes were measured using daily logs, and physical activity was measured objectively using accelerometers. Results: Fifty participants (48{\%} female, mean age 66 ± 8 years) participated for an average of 16 ± 9 preoperative weeks. Participants reported overall means of 126 ± 83 weekly minutes of aerobic exercise and 39 ± 33 weekly minutes of strengthening exercise in daily logs. Participants performed 158.7 ± 146.7 weekly minutes of accelerometer-measured moderate-to-vigorous physical activity. There were no significant differences in exercise or physical activity between treatment phases. Conclusions: These findings suggest that it is feasible to target the entire preoperative course for exercise prescription. Although participants exceeded aerobic exercise recommendations on average, we observed low strengthening exercise adherence and wide variability in self-reported exercise and accelerometer physical activity variables. These findings suggest that additional support, including program adaptations, may be necessary to overcome barriers to exercise or improve motivation when prescribing exercise in this clinical scenario.",
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author = "Parker, {Nathan H.} and An Ngo-Huang and Rebecca Lee and O’Connor, {Daniel P.} and Basen-Engquist, {Karen M.} and Petzel, {Maria Q.B.} and Xuemei Wang and Lianchun Xiao and Fogelman, {David R.} and Schadler, {Keri L.} and Simpson, {Richard J.} and Fleming, {Jason B.} and Lee, {Jeffrey E.} and Varadhachary, {Gauri R.} and Sahai, {Sunil K.} and Katz, {Matthew H.G.}",
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AU - Parker, Nathan H.

AU - Ngo-Huang, An

AU - Lee, Rebecca

AU - O’Connor, Daniel P.

AU - Basen-Engquist, Karen M.

AU - Petzel, Maria Q.B.

AU - Wang, Xuemei

AU - Xiao, Lianchun

AU - Fogelman, David R.

AU - Schadler, Keri L.

AU - Simpson, Richard J.

AU - Fleming, Jason B.

AU - Lee, Jeffrey E.

AU - Varadhachary, Gauri R.

AU - Sahai, Sunil K.

AU - Katz, Matthew H.G.

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N2 - Abstract: Purpose: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. Methods: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence. Self-reported aerobic and strengthening exercise minutes were measured using daily logs, and physical activity was measured objectively using accelerometers. Results: Fifty participants (48% female, mean age 66 ± 8 years) participated for an average of 16 ± 9 preoperative weeks. Participants reported overall means of 126 ± 83 weekly minutes of aerobic exercise and 39 ± 33 weekly minutes of strengthening exercise in daily logs. Participants performed 158.7 ± 146.7 weekly minutes of accelerometer-measured moderate-to-vigorous physical activity. There were no significant differences in exercise or physical activity between treatment phases. Conclusions: These findings suggest that it is feasible to target the entire preoperative course for exercise prescription. Although participants exceeded aerobic exercise recommendations on average, we observed low strengthening exercise adherence and wide variability in self-reported exercise and accelerometer physical activity variables. These findings suggest that additional support, including program adaptations, may be necessary to overcome barriers to exercise or improve motivation when prescribing exercise in this clinical scenario.

AB - Abstract: Purpose: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. Methods: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence. Self-reported aerobic and strengthening exercise minutes were measured using daily logs, and physical activity was measured objectively using accelerometers. Results: Fifty participants (48% female, mean age 66 ± 8 years) participated for an average of 16 ± 9 preoperative weeks. Participants reported overall means of 126 ± 83 weekly minutes of aerobic exercise and 39 ± 33 weekly minutes of strengthening exercise in daily logs. Participants performed 158.7 ± 146.7 weekly minutes of accelerometer-measured moderate-to-vigorous physical activity. There were no significant differences in exercise or physical activity between treatment phases. Conclusions: These findings suggest that it is feasible to target the entire preoperative course for exercise prescription. Although participants exceeded aerobic exercise recommendations on average, we observed low strengthening exercise adherence and wide variability in self-reported exercise and accelerometer physical activity variables. These findings suggest that additional support, including program adaptations, may be necessary to overcome barriers to exercise or improve motivation when prescribing exercise in this clinical scenario.

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KW - Aerobic exercise

KW - Cancer survivorship

KW - Prehabilitation

KW - Strengthening exercise

KW - Surgery

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