Physical activity and Alzheimer's disease: A narrative review

Piotr Gronek, Stefan Balko, Joanna Gronek, Adam Zajac, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain C.T. Clark, Fang Yu

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Although age is a dominant risk factor for Alzheimer's disease (AD), epidemiological studies have shown that physical activity may significantly decrease age-related risks for AD, and indeed mitigate the impact in existing diagnosis. The aim of this study was to perform a narrative review on the preventative, and mitigating, effects of physical activity on AD onset, including genetic factors, mechanism of action and physical activity typology. In this article, we conducted a narrative review of the influence physical activity and exercise have on AD, utilising key terms related to AD, physical activity, mechanism and prevention, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action. On the basis of this review, it is evident that physical activity and exercise may be incorporated in AD, notwithstanding, a greater number of high-quality randomised controlled trials are needed, moreover, physical activity typology must be acutely considered, primarily due to a dearth of research on the efficacy of physical activity types other than aerobic.

Original languageEnglish (US)
Pages (from-to)1282-1292
Number of pages11
JournalAging and Disease
Volume10
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Aging
  • Alzheimer's disease
  • Exercise
  • Physical activity
  • Prevention

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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