Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic

Andrew Storfer, Michael E. Alfaro, Benjamin J. Ridenhour, James K. Jancovich, Stephen G. Mech, Matthew J. Parris, James Collins

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Distinguishing whether pathogens are novel or endemic is critical for controlling emerging infectious diseases, an increasing threat to wildlife and human health. To test the endemic vs. novel pathogen hypothesis, we present a unique analysis of intraspecific host-pathogen phylogenetic concordance of tiger salamanders and an emerging Ranavirus throughout Western North America. There is significant non-concordance of host and virus gene trees, suggesting pathogen novelty. However, non-concordance has likely resulted from virus introductions by human movement of infected salamanders. When human-associated viral introductions are excluded, host and virus gene trees are identical, strongly supporting coevolution and endemism. A laboratory experiment showed an introduced virus strain is significantly more virulent than endemic strains, likely due to artificial selection for high virulence. Thus, our analysis of intraspecific phylogenetic concordance revealed that human introduction of viruses is the mechanism underlying tree non-concordance and possibly disease emergence via artificial selection.

Original languageEnglish (US)
Pages (from-to)1075-1083
Number of pages9
JournalEcology Letters
Volume10
Issue number11
DOIs
StatePublished - Nov 2007

Fingerprint

virus
pathogen
phylogenetics
viruses
pathogens
phylogeny
artificial selection
Ranavirus
Ambystoma
emerging diseases
gene
infectious disease
coevolution
endemism
virulence
salamanders and newts
human health
wildlife
indigenous species
genes

Keywords

  • Ambystoma tigrinum
  • Ambystoma tigrinum virus
  • Amphibian declines
  • Emerging diseases
  • Phylogenetic concordance
  • Virulence

ASJC Scopus subject areas

  • Ecology

Cite this

Storfer, A., Alfaro, M. E., Ridenhour, B. J., Jancovich, J. K., Mech, S. G., Parris, M. J., & Collins, J. (2007). Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic. Ecology Letters, 10(11), 1075-1083. https://doi.org/10.1111/j.1461-0248.2007.01102.x

Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic. / Storfer, Andrew; Alfaro, Michael E.; Ridenhour, Benjamin J.; Jancovich, James K.; Mech, Stephen G.; Parris, Matthew J.; Collins, James.

In: Ecology Letters, Vol. 10, No. 11, 11.2007, p. 1075-1083.

Research output: Contribution to journalArticle

Storfer, A, Alfaro, ME, Ridenhour, BJ, Jancovich, JK, Mech, SG, Parris, MJ & Collins, J 2007, 'Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic', Ecology Letters, vol. 10, no. 11, pp. 1075-1083. https://doi.org/10.1111/j.1461-0248.2007.01102.x
Storfer A, Alfaro ME, Ridenhour BJ, Jancovich JK, Mech SG, Parris MJ et al. Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic. Ecology Letters. 2007 Nov;10(11):1075-1083. https://doi.org/10.1111/j.1461-0248.2007.01102.x
Storfer, Andrew ; Alfaro, Michael E. ; Ridenhour, Benjamin J. ; Jancovich, James K. ; Mech, Stephen G. ; Parris, Matthew J. ; Collins, James. / Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic. In: Ecology Letters. 2007 ; Vol. 10, No. 11. pp. 1075-1083.
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