Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation

Andrew N. Webber; Richard Malkin

doi:10.1016/0014-5793(90)80749-9

Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation

Andrew N. Webber, Richard Malkin

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The photosystem I (PS I) reaction-centre polypeptides, encoded by the psaA and psaB genes, are shown to contain several highly conserved leucine repeats, consisting of a leucine residue every seventh amino acid, similar to the leucine zipper motifs known to mediate DNA-binding polypeptide dimerisation. In each of the PSI reaction-centre subunits the leucine zipper motif precedes highly conserved cysteine residues which have been proposed to ligate the interpolypeptide [4Fe-4S] centre, Fx. We propose that PS I reaction-centre dimerisation and [4Fe-4S] centre formation are mediated through the leucine zipper.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	FEBS Letters
Volume	264
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(90)80749-9
State	Published - May 7 1990
Externally published	Yes

Keywords

Iron-sulphur center
Leucine zipper
Photosystem I
Reaction center

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(90)80749-9

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title = "Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation",

abstract = "The photosystem I (PS I) reaction-centre polypeptides, encoded by the psaA and psaB genes, are shown to contain several highly conserved leucine repeats, consisting of a leucine residue every seventh amino acid, similar to the leucine zipper motifs known to mediate DNA-binding polypeptide dimerisation. In each of the PSI reaction-centre subunits the leucine zipper motif precedes highly conserved cysteine residues which have been proposed to ligate the interpolypeptide [4Fe-4S] centre, Fx. We propose that PS I reaction-centre dimerisation and [4Fe-4S] centre formation are mediated through the leucine zipper.",

keywords = "Iron-sulphur center, Leucine zipper, Photosystem I, Reaction center",

author = "Webber, {Andrew N.} and Richard Malkin",

note = "Funding Information: Acknowledgements: We thankD r R. Max Wynn for valuabled iscus-sions. Supportedb y a grant from the NSF to R.M.",

year = "1990",

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doi = "10.1016/0014-5793(90)80749-9",

language = "English (US)",

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T1 - Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation

AU - Webber, Andrew N.

AU - Malkin, Richard

N1 - Funding Information: Acknowledgements: We thankD r R. Max Wynn for valuabled iscus-sions. Supportedb y a grant from the NSF to R.M.

PY - 1990/5/7

Y1 - 1990/5/7

N2 - The photosystem I (PS I) reaction-centre polypeptides, encoded by the psaA and psaB genes, are shown to contain several highly conserved leucine repeats, consisting of a leucine residue every seventh amino acid, similar to the leucine zipper motifs known to mediate DNA-binding polypeptide dimerisation. In each of the PSI reaction-centre subunits the leucine zipper motif precedes highly conserved cysteine residues which have been proposed to ligate the interpolypeptide [4Fe-4S] centre, Fx. We propose that PS I reaction-centre dimerisation and [4Fe-4S] centre formation are mediated through the leucine zipper.

AB - The photosystem I (PS I) reaction-centre polypeptides, encoded by the psaA and psaB genes, are shown to contain several highly conserved leucine repeats, consisting of a leucine residue every seventh amino acid, similar to the leucine zipper motifs known to mediate DNA-binding polypeptide dimerisation. In each of the PSI reaction-centre subunits the leucine zipper motif precedes highly conserved cysteine residues which have been proposed to ligate the interpolypeptide [4Fe-4S] centre, Fx. We propose that PS I reaction-centre dimerisation and [4Fe-4S] centre formation are mediated through the leucine zipper.

KW - Iron-sulphur center

KW - Leucine zipper

KW - Photosystem I

KW - Reaction center

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JO - FEBS Letters

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Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation

Abstract

Keywords

ASJC Scopus subject areas

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