Phospholipid lung surfactant and nanoparticle surface toxicity: Lessons from diesel soots and silicate dusts

William E. Wallace, Michael J. Keane, David K. Murray, William P. Chisholm, Andrew Maynard, Tong Man Ong

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Because of their small size, the specific surface areas of nanoparticulate materials (NP), described as particles having at least one dimension smaller than 100 nm, can be large compared with micrometer-sized respirable particles. This high specific surface area or nanostructural surface properties may affect NP toxicity in comparison with micrometer-sized respirable particles of the same overall composition. Respirable particles depositing on the deep lung surfaces of the respiratory bronchioles or alveoli will contact pulmonary surfactants in the surface hypophase. Diesel exhaust ultrafine particles and respirable silicate micrometer-sized insoluble particles can adsorb components of that surfactant onto the particle surfaces, conditioning the particles surfaces and affecting their in vitro expression of cytotoxicity or genotoxicity. Those effects can be particle surface composition-specific. Effects of particle surface conditioning by a primary component of phospholipid pulmonary surfactant, diacyl phosphatidyl choline, are reviewed for in vitro expression of genotoxicity by diesel exhaust particles and of cytotoxicity by respirable quartz and aluminosilicate kaolin clay particles. Those effects suggest methods and cautions for assaying and interpreting NP properties and biological activities.

Original languageEnglish (US)
Pages (from-to)23-38
Number of pages16
JournalJournal of Nanoparticle Research
Volume9
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Soot
Silicates
Phospholipids
Surfactant
soot
Toxicity
Lung
Surface-Active Agents
toxicity
lungs
Nanoparticles
Dust
silicates
Surface active agents
dust
surfactants
nanoparticles
Pulmonary Surfactants
Vehicle Emissions
Cytotoxicity

Keywords

  • Cytotoxicity
  • Dipalmitoyl phosphatidyl choline
  • Genotoxicity
  • Nanoparticle
  • Occupational health
  • Particle surface
  • Phospholipid
  • Silicosis
  • Surface analysis
  • Surfactant
  • Toxicity

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)
  • Materials Science (miscellaneous)

Cite this

Phospholipid lung surfactant and nanoparticle surface toxicity : Lessons from diesel soots and silicate dusts. / Wallace, William E.; Keane, Michael J.; Murray, David K.; Chisholm, William P.; Maynard, Andrew; Ong, Tong Man.

In: Journal of Nanoparticle Research, Vol. 9, No. 1, 01.2007, p. 23-38.

Research output: Contribution to journalArticle

Wallace, William E. ; Keane, Michael J. ; Murray, David K. ; Chisholm, William P. ; Maynard, Andrew ; Ong, Tong Man. / Phospholipid lung surfactant and nanoparticle surface toxicity : Lessons from diesel soots and silicate dusts. In: Journal of Nanoparticle Research. 2007 ; Vol. 9, No. 1. pp. 23-38.
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