(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues

Amos B. Smith, Thomas M. Razler, George Pettit, Jean Chapuis

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

(Chemical Equation Presented) Effective, scalable total syntheses and biological evaluation of six phorboxazole A analogues (1-6) have been achieved. Importantly, the C(45-46)-saturated, C(45-46)-alkenyl, and the C(45-46)-E-chloroalkenyl congeners (4, 5, and 6, respectively) reveal low nanomolar tumor cell growth inhibitory activity (GI50's) similar to or, in some cell lines, greater than that of the phorboxazoles across a diverse panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)4403-4406
Number of pages4
JournalOrganic Letters
Volume7
Issue number20
DOIs
StatePublished - Sep 29 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of '(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues'. Together they form a unique fingerprint.

  • Cite this