Abstract
(Chemical Equation Presented) Effective, scalable total syntheses and biological evaluation of six phorboxazole A analogues (1-6) have been achieved. Importantly, the C(45-46)-saturated, C(45-46)-alkenyl, and the C(45-46)-E-chloroalkenyl congeners (4, 5, and 6, respectively) reveal low nanomolar tumor cell growth inhibitory activity (GI50's) similar to or, in some cell lines, greater than that of the phorboxazoles across a diverse panel of human cancer cell lines.
Original language | English (US) |
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Pages (from-to) | 4403-4406 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 20 |
DOIs | |
State | Published - Sep 29 2005 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry