(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues

Amos B. Smith, Thomas M. Razler, George R. Pettit, Jean Charles Chapuis

Research output: Contribution to journalArticle

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Abstract

(Chemical Equation Presented) Effective, scalable total syntheses and biological evaluation of six phorboxazole A analogues (1-6) have been achieved. Importantly, the C(45-46)-saturated, C(45-46)-alkenyl, and the C(45-46)-E-chloroalkenyl congeners (4, 5, and 6, respectively) reveal low nanomolar tumor cell growth inhibitory activity (GI50's) similar to or, in some cell lines, greater than that of the phorboxazoles across a diverse panel of human cancer cell lines.

LanguageEnglish (US)
Pages4403-4406
Number of pages4
JournalOrganic Letters
Volume7
Issue number20
DOIs
StatePublished - Sep 29 2005

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cultured cells
Cells
analogs
congeners
Cell Line
Cell growth
Tumors
Neoplasms
tumors
cancer
evaluation
synthesis
Growth
phorboxazole A

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues. / Smith, Amos B.; Razler, Thomas M.; Pettit, George R.; Chapuis, Jean Charles.

In: Organic Letters, Vol. 7, No. 20, 29.09.2005, p. 4403-4406.

Research output: Contribution to journalArticle

Smith, Amos B. ; Razler, Thomas M. ; Pettit, George R. ; Chapuis, Jean Charles. / (+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues. In: Organic Letters. 2005 ; Vol. 7, No. 20. pp. 4403-4406
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