Phenolic acid amides

A new type of DNA strand scission agent from Piper caninum

Ji Ma, Shannon H. Jones, Sidney Hecht

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu2+. Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-cinnamoylpyrrolidine (3). Compounds 1-3 represent a structurally new type of DNA strand scission agent.

Original languageEnglish (US)
Pages (from-to)3885-3889
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number14
DOIs
StatePublished - Jul 15 2004
Externally publishedYes

Fingerprint

Piper
Amides
Tyramine
DNA
Complex Mixtures
Bioassay
Plant Extracts
Fractionation
Biological Assay
Assays
Plasmids
phenolic acid

Keywords

  • Chemotherapy
  • Natural products
  • Nucleic acids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Phenolic acid amides : A new type of DNA strand scission agent from Piper caninum. / Ma, Ji; Jones, Shannon H.; Hecht, Sidney.

In: Bioorganic and Medicinal Chemistry, Vol. 12, No. 14, 15.07.2004, p. 3885-3889.

Research output: Contribution to journalArticle

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