Phenolic acid amides: A new type of DNA strand scission agent from Piper caninum

Ji Ma, Shannon H. Jones, Sidney M. Hecht

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu2+. Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-cinnamoylpyrrolidine (3). Compounds 1-3 represent a structurally new type of DNA strand scission agent.

Original languageEnglish (US)
Pages (from-to)3885-3889
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number14
DOIs
StatePublished - Jul 15 2004
Externally publishedYes

Keywords

  • Chemotherapy
  • Natural products
  • Nucleic acids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Phenolic acid amides: A new type of DNA strand scission agent from Piper caninum'. Together they form a unique fingerprint.

  • Cite this