Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals

John Spence, Richard Kirian, Xiaoyu Wang, Uwe Weierstall, Kevin Schmidt, Thomas White, Anton Barty, Henry N. Chapman, Stefano Marchesini, James Holton

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The scattering between Bragg reflections from nanocrystals is used to aid solution of the phase problem. We describe a method for reconstructing the charge density of a typical molecule within a single unit cell, if sufficiently finely-sampled "snap-shot" diffraction data (as provided a free-electron X-ray laser) are available from many nanocrystals of different sizes lying in random orientations. By using information on the particle-size distribution within the patterns, this digital method succeeds, using all the data, without knowledge of the distribution of particle size or requiring atomic-resolution data.

Original languageEnglish (US)
Pages (from-to)2866-2873
Number of pages8
JournalOptics Express
Volume19
Issue number4
DOIs
StatePublished - Feb 14 2011

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nanocrystals
particle size distribution
diffraction
free electrons
shot
x rays
cells
scattering
lasers
molecules

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals. / Spence, John; Kirian, Richard; Wang, Xiaoyu; Weierstall, Uwe; Schmidt, Kevin; White, Thomas; Barty, Anton; Chapman, Henry N.; Marchesini, Stefano; Holton, James.

In: Optics Express, Vol. 19, No. 4, 14.02.2011, p. 2866-2873.

Research output: Contribution to journalArticle

Spence, John ; Kirian, Richard ; Wang, Xiaoyu ; Weierstall, Uwe ; Schmidt, Kevin ; White, Thomas ; Barty, Anton ; Chapman, Henry N. ; Marchesini, Stefano ; Holton, James. / Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals. In: Optics Express. 2011 ; Vol. 19, No. 4. pp. 2866-2873.
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