Pharmacokinetic principles of immunosuppressive drugs

Titte R. Srinivas, Herwig Ulf Meier-Kriesche, Bruce Kaplan

Research output: Contribution to journalShort survey

48 Scopus citations

Abstract

A basic tenet of clinical pharmacology is that the pharmacologic activity of an exogenously administered agent is related to the free drug concentration available at its receptor or ligand-binding site. The discipline of pharmacokinetics can be defined as the study of the processes that lead to the availability of an agent to its site of action. In this review we will discuss basic principles of pharmacokinetics that govern the absorption, distribution, metabolism, elimination and binding of immunosuppressive drugs commonly utilized in whole organ transplantation. In a discipline such as organ transplantation, where the agents utilized carry significant toxicity and where failure of efficacy can have dire consequences, knowledge of the pharmacokinetics of the agents utilized has become a basic skill for all transplant professionals. In this review we describe some of the underlying principles that govern the disposition of the agents commonly utilized in solid organ transplantation. In addition, we hope this review will help in understanding some of the basic drug interactions encountered in transplant practice.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalAmerican Journal of Transplantation
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2005

Keywords

  • Clinical pharmacology
  • Immunosuppressants
  • Pharmacokinetics
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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