Peto's Paradox: How has evolution solved the problem of cancer prevention?

Marc Tollis, Amy M. Boddy, Carlo Maley

Research output: Contribution to journalComment/debatepeer-review

21 Scopus citations

Abstract

The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto's Paradox. We discuss what is known about Peto's Paradox and provide hints of what is yet to be discovered.

Original languageEnglish (US)
Article number60
JournalBMC Biology
Volume15
Issue number1
DOIs
StatePublished - Jul 13 2017

ASJC Scopus subject areas

  • Biotechnology
  • Structural Biology
  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Plant Science
  • Developmental Biology
  • Cell Biology

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