Perspectives on genetic and genomic technologies in an academic medical center: The duke experience

Sara Huston Katsanis, Mollie A. Minear, Allison Vorderstrasse, Nancy Yang, Jason W. Reeves, Tejinder Rakhra-Burris, Robert Cook-Deegan, Geoffrey S. Ginsburg, Leigh Ann Simmons

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations


    In this age of personalized medicine, genetic and genomic testing is expected to become instrumental in health care delivery, but little is known about its actual implementation in clinical practice. Methods. We surveyed Duke faculty and healthcare providers to examine the extent of genetic and genomic testing adoption. We assessed providers’ use of genetic and genomic testing options and indications in clinical practice, providers’ awareness of pharmacogenetic applications, and providers’ opinions on returning research-generated genetic test results to participants. Most clinician respondents currently use family history routinely in their clinical practice, but only 18 percent of clinicians use pharmacogenetics. Only two respondents correctly identified the number of drug package inserts with pharmacogenetic indications. We also found strong support for the return of genetic research results to participants. Our results demonstrate that while Duke healthcare providers are enthusiastic about genomic technologies, use of genomic tools outside of research has been limited. Respondents favor return of research-based genetic results to participants, but clinicians lack knowledge about pharmacogenetic applications. We identified challenges faced by this institution when implementing genetic and genomic testing into patient care that should inform a policy and education agenda to improve provider support and clinician-researcher partnerships.

    Original languageEnglish (US)
    Pages (from-to)67-82
    Number of pages16
    JournalJournal of Personalized Medicine
    Issue number2
    StatePublished - Apr 3 2015


    • Clinical implementation
    • Genetic tests
    • Genomic tests
    • Knowledge gaps
    • Personalized medicine
    • Pharmacogenetics
    • Physician education
    • Return of research results

    ASJC Scopus subject areas

    • Medicine (miscellaneous)


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