Perspective: A program to improve protein biomarker discovery for cancer

Ruedi Aebersold, Leigh Anderson, Richard Caprioli, Brian Druker, Leland Hartwell, Richard Smith

Research output: Contribution to journalReview article

118 Scopus citations

Abstract

Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.

Original languageEnglish (US)
Pages (from-to)1104-1109
Number of pages6
JournalJournal of Proteome Research
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

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Keywords

  • Biomarker
  • Cancer
  • Discovery
  • Informatics
  • Reagents
  • Research platform

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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