Permanent Coverage of Large Burn Wounds with Autologous Cultured Human Epithelium

G. Gregory Gallico, Nicholas E. O'connor, Carolyn C. Compton, Olaniyi Kehinde, Howard Green

Research output: Contribution to journalArticlepeer-review

1057 Scopus citations

Abstract

WHEN burns are so extensive that skin grafts obtainable from remaining donor sites are insufficient to provide wound coverage, a new source of autograft must be found. Human epidermal cells from a small skin-biopsy sample can be cultured to produce coherent epithelial sheets sufficient to cover the entire body surface.[1 2 When this epithelium was applied to wounds on athymic mice it generated a human epidermis.3 Autologous cultured epithelium placed on small burn wounds in adults'1 and children5 adhered and generated a permanent epidermis similar to that resulting from split-thickness skin grafts. We report here that in two children who sustained.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalNew England Journal of Medicine
Volume311
Issue number7
DOIs
StatePublished - Aug 16 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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