Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory

Matthew J. Huentelman; Dietrich A. Stephan; Joshua Talboom; Jason J. Corneveaux; David M. Reiman; Jill D. Gerber; Carol A. Barnes; Gene E. Alexander; Eric M. Reiman; Heather Bimonte-Nelson

doi:10.1037/a0014260

Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory

Matthew J. Huentelman, Dietrich A. Stephan, Joshua Talboom, Jason J. Corneveaux, David M. Reiman, Jill D. Gerber, Carol A. Barnes, Gene E. Alexander, Eric M. Reiman, Heather Bimonte-Nelson

Psychology

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.

Original language	English (US)
Pages (from-to)	218-223
Number of pages	6
Journal	Behavioral Neuroscience
Volume	123
Issue number	1
DOIs	https://doi.org/10.1037/a0014260
State	Published - Feb 2009

Keywords

ROCK
aging
fasudil
learning
memory

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1037/a0014260

Cite this

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abstract = "Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.",

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AU - Talboom, Joshua

AU - Corneveaux, Jason J.

AU - Reiman, David M.

AU - Gerber, Jill D.

AU - Barnes, Carol A.

AU - Alexander, Gene E.

AU - Reiman, Eric M.

AU - Bimonte-Nelson, Heather

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AB - Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.

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Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory

Abstract

Keywords

ASJC Scopus subject areas

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