Perceptual auditory gap detection deficits in male BXSB mice with cerebrocortical ectopias

Matthew G. Clark, Gordon F. Sherman, Heather A. Bimonte, R. Holly Fitch

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Underlying impairments in rapid auditory processing may contribute to disrupted phonological processing, which in turn characterizes developmental language impairment (LI). Identification of a neurobiological feature of LI that is associated with auditory deficits would further support this model. Accordingly, we found that adult male rats with induced cortical malformations were impaired in rapid auditory processing. Since 40-60% of BXSB mice exhibit spontaneous focal cerebrocortical ectopias (as seen in dyslexics brains), we assessed auditory gap detection in adult male BXSB mice. Ectopic mice were significantly worse than non-ectopics in detecting a 5 ms silent gap, but were not significantly impaired at longer gap durations (10-100 ms). Our results confirm that focal cortical malformations are associated with impairments in rapid auditory processing. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
Issue number4
StatePublished - Mar 20 2000
Externally publishedYes


  • Auditory discrimination
  • Cortex
  • Dyslexia
  • Language impairment
  • Phonological deficits
  • Reflex modification

ASJC Scopus subject areas

  • Neuroscience(all)


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