Peptide to facilitate transport of tagged proteins across the blood brain barrier

Michael Sierks (Inventor)

Research output: Patent

Abstract

The treatment of brain disorders remains a considerable medical challenge, primarily because of the blood brain barrier (BBB). This protective mechanism for the brain can be a severe hindrance to treating and diagnosing many brain disorders. While there has been research into this, the ability to deliver substances into the brain is still a challenge. Thus, compounds that enable transport across the BBB could have significant impact in brain diagnostics, therapeutics and research. Professor Michael Sierks at Arizona State University has developed a novel peptide tag that efficiently facilitates transport of therapeutics across the BBB and into and out of cells within the brain. The utility of this peptide tag was confirmed in a mouse model of Parkinson's disease, where peptide-tagged therapeutic antibodies were transported from the blood stream, across the BBB and into the brain. Mice treated with these peptide-tagged antibodies showed significant improvement in behavior and pathology compared to control mice. This novel peptide not only crosses the BBB, but also enters and exits brain cells and may provide an unprecedented approach to treating and diagnosing brain disorders, as well as understanding and furthering brain research. Potential Applications Targeting therapeutics to the brain for diagnosing and treating brain disorders Alzheimer's Disease Parkinson's Disease ALS Dementia Brain tumors Brain infections Neural research Benefits and Advantages Transports therapeutics not only across the BBB, but also into and out of brain cells The peptide tag is short enough to facilitate ready use in different vector constructs Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Sierks' directory webpage Dr. Sierks' laboratory webpage
Original languageEnglish (US)
StatePublished - Feb 28 2013

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Blood-Brain Barrier
Carrier Proteins
Peptides
Brain
Brain Diseases
Research
Parkinson Disease
Inventors
Therapeutic Human Experimentation
Directories
Aptitude
Antibodies
Therapeutics
Brain Neoplasms
Dementia
Alzheimer Disease
Pathology
Infection

Cite this

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abstract = "The treatment of brain disorders remains a considerable medical challenge, primarily because of the blood brain barrier (BBB). This protective mechanism for the brain can be a severe hindrance to treating and diagnosing many brain disorders. While there has been research into this, the ability to deliver substances into the brain is still a challenge. Thus, compounds that enable transport across the BBB could have significant impact in brain diagnostics, therapeutics and research. Professor Michael Sierks at Arizona State University has developed a novel peptide tag that efficiently facilitates transport of therapeutics across the BBB and into and out of cells within the brain. The utility of this peptide tag was confirmed in a mouse model of Parkinson's disease, where peptide-tagged therapeutic antibodies were transported from the blood stream, across the BBB and into the brain. Mice treated with these peptide-tagged antibodies showed significant improvement in behavior and pathology compared to control mice. This novel peptide not only crosses the BBB, but also enters and exits brain cells and may provide an unprecedented approach to treating and diagnosing brain disorders, as well as understanding and furthering brain research. Potential Applications Targeting therapeutics to the brain for diagnosing and treating brain disorders Alzheimer's Disease Parkinson's Disease ALS Dementia Brain tumors Brain infections Neural research Benefits and Advantages Transports therapeutics not only across the BBB, but also into and out of brain cells The peptide tag is short enough to facilitate ready use in different vector constructs Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Sierks' directory webpage Dr. Sierks' laboratory webpage",
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