Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials

Research output: Contribution to journalReview article

Abstract

Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize other molecules with nanoscale precision. In this Topical Review, we discuss covalent conjugates of peptides and DNA for creating bioactive materials that can interface with cells. In particular, we focus on two areas. The first is multivalent presentation of peptides on a DNA scaffold, both linear assemblies and more complex nanostructures. The second is the reversible tuning of the extracellular environment - like ligand presentation, stiffness, and hierarchical morphology - in peptide-DNA biomaterials. These examples highlight the potential for creating highly potent materials with benefits not possible with either molecule alone, and we outline a number of future directions and applications for peptide-DNA conjugates.

Original languageEnglish (US)
JournalBioconjugate Chemistry
DOIs
StatePublished - Jan 1 2019

Fingerprint

Nanostructures
Oligonucleotides
Nanostructured materials
Peptides
DNA
Molecules
Scaffolds
Biocompatible Materials
Scaffolds (biology)
Bioactivity
Biomaterials
Tuning
Ligands
Stiffness
Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials. / Stephanopoulos, Nicholas.

In: Bioconjugate Chemistry, 01.01.2019.

Research output: Contribution to journalReview article

@article{8663980211a544e9af79b4d2c4c7f0a4,
title = "Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials",
abstract = "Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize other molecules with nanoscale precision. In this Topical Review, we discuss covalent conjugates of peptides and DNA for creating bioactive materials that can interface with cells. In particular, we focus on two areas. The first is multivalent presentation of peptides on a DNA scaffold, both linear assemblies and more complex nanostructures. The second is the reversible tuning of the extracellular environment - like ligand presentation, stiffness, and hierarchical morphology - in peptide-DNA biomaterials. These examples highlight the potential for creating highly potent materials with benefits not possible with either molecule alone, and we outline a number of future directions and applications for peptide-DNA conjugates.",
author = "Nicholas Stephanopoulos",
year = "2019",
month = "1",
day = "1",
doi = "10.1021/acs.bioconjchem.9b00259",
language = "English (US)",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials

AU - Stephanopoulos, Nicholas

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize other molecules with nanoscale precision. In this Topical Review, we discuss covalent conjugates of peptides and DNA for creating bioactive materials that can interface with cells. In particular, we focus on two areas. The first is multivalent presentation of peptides on a DNA scaffold, both linear assemblies and more complex nanostructures. The second is the reversible tuning of the extracellular environment - like ligand presentation, stiffness, and hierarchical morphology - in peptide-DNA biomaterials. These examples highlight the potential for creating highly potent materials with benefits not possible with either molecule alone, and we outline a number of future directions and applications for peptide-DNA conjugates.

AB - Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize other molecules with nanoscale precision. In this Topical Review, we discuss covalent conjugates of peptides and DNA for creating bioactive materials that can interface with cells. In particular, we focus on two areas. The first is multivalent presentation of peptides on a DNA scaffold, both linear assemblies and more complex nanostructures. The second is the reversible tuning of the extracellular environment - like ligand presentation, stiffness, and hierarchical morphology - in peptide-DNA biomaterials. These examples highlight the potential for creating highly potent materials with benefits not possible with either molecule alone, and we outline a number of future directions and applications for peptide-DNA conjugates.

UR - http://www.scopus.com/inward/record.url?scp=85066500879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066500879&partnerID=8YFLogxK

U2 - 10.1021/acs.bioconjchem.9b00259

DO - 10.1021/acs.bioconjchem.9b00259

M3 - Review article

C2 - 31082220

AN - SCOPUS:85066500879

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

ER -