PDK1 and HR46 gene homologs tie social behavior to ovary signals

Ying Wang, Gro Amdam, Olav Rueppell, Megan A. Wallrichs, M. Kim Fondrk, Osman Kaftanoglu, Robert Page

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.

Original languageEnglish (US)
Article numbere4899
JournalPLoS One
Volume4
Issue number4
DOIs
StatePublished - Apr 2 2009

Fingerprint

Social Behavior
social behavior
Ovary
Plant Nectar
Genes
foraging
Bees
Pollen
polyethism
Honey
Quantitative Trait Loci
nectar
genes
Personnel
pollen
reproductive traits
Behavioral Genetics
honey bees
quantitative trait loci
Resource Allocation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wang, Y., Amdam, G., Rueppell, O., Wallrichs, M. A., Fondrk, M. K., Kaftanoglu, O., & Page, R. (2009). PDK1 and HR46 gene homologs tie social behavior to ovary signals. PLoS One, 4(4), [e4899]. https://doi.org/10.1371/journal.pone.0004899

PDK1 and HR46 gene homologs tie social behavior to ovary signals. / Wang, Ying; Amdam, Gro; Rueppell, Olav; Wallrichs, Megan A.; Fondrk, M. Kim; Kaftanoglu, Osman; Page, Robert.

In: PLoS One, Vol. 4, No. 4, e4899, 02.04.2009.

Research output: Contribution to journalArticle

Wang, Y, Amdam, G, Rueppell, O, Wallrichs, MA, Fondrk, MK, Kaftanoglu, O & Page, R 2009, 'PDK1 and HR46 gene homologs tie social behavior to ovary signals', PLoS One, vol. 4, no. 4, e4899. https://doi.org/10.1371/journal.pone.0004899
Wang Y, Amdam G, Rueppell O, Wallrichs MA, Fondrk MK, Kaftanoglu O et al. PDK1 and HR46 gene homologs tie social behavior to ovary signals. PLoS One. 2009 Apr 2;4(4). e4899. https://doi.org/10.1371/journal.pone.0004899
Wang, Ying ; Amdam, Gro ; Rueppell, Olav ; Wallrichs, Megan A. ; Fondrk, M. Kim ; Kaftanoglu, Osman ; Page, Robert. / PDK1 and HR46 gene homologs tie social behavior to ovary signals. In: PLoS One. 2009 ; Vol. 4, No. 4.
@article{7e27b75a07d447afae017ca3067ddc2a,
title = "PDK1 and HR46 gene homologs tie social behavior to ovary signals",
abstract = "The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.",
author = "Ying Wang and Gro Amdam and Olav Rueppell and Wallrichs, {Megan A.} and Fondrk, {M. Kim} and Osman Kaftanoglu and Robert Page",
year = "2009",
month = "4",
day = "2",
doi = "10.1371/journal.pone.0004899",
language = "English (US)",
volume = "4",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - PDK1 and HR46 gene homologs tie social behavior to ovary signals

AU - Wang, Ying

AU - Amdam, Gro

AU - Rueppell, Olav

AU - Wallrichs, Megan A.

AU - Fondrk, M. Kim

AU - Kaftanoglu, Osman

AU - Page, Robert

PY - 2009/4/2

Y1 - 2009/4/2

N2 - The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.

AB - The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.

UR - http://www.scopus.com/inward/record.url?scp=64549115923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64549115923&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0004899

DO - 10.1371/journal.pone.0004899

M3 - Article

C2 - 19340296

AN - SCOPUS:64549115923

VL - 4

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e4899

ER -