Pax3/7 expression coincides with MyoD during chronic skeletal muscle overload

Jon Philippe K. Hyatt, Gary E. McCall, Elizabeth M. Kander, Hui Zhong, Roland R. Roy, Kimberly A. Huey

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (≤7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes. Pax3 and 7 mRNA were higher than control within 12 h after initiation of overload, preceded the increase in MyoD mRNA on day 1, and peaked on day 2. On days 3 and 7, Pax7 mRNA remained higher than control, suggesting that satellite cell self-renewal was occurring. Pax3 and 7 and MyoD protein levels were higher than control on days 2 and 3. These data indicate that Pax3 and 7 coordinate the recapitulation of developmental-like regulatory mechanisms in response to growth-inducing stimuli in adult skeletal muscle, presumably through activation of satellite cells.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalMuscle and Nerve
Volume38
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • Functional overload
  • Muscle regulatory factor
  • Plantaris
  • Satellite cell

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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