@article{4eff984ff3434c4cb5bac87debfc4e65,
title = "Patterns of waking EEG spectral power in chemically intolerant individuals during repeated chemical exposures",
abstract = "Previous studies indicate that low level chemical intolerance (CI) is a symptom of several different controversial conditions with neuropsychiatric features, e.g., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and 'Persian Gulf Syndrome'. Prior studies suggest that limbic and/or mesolimbic sensitization may contribute to development of CI. The purpose of this report was to document the waking electroencephalographic (EEG) patterns of individuals with CI during chemical exposures presented over repeated sessions. Three groups of adult subjects who were recruited from the community participated in the study: self-reported CI who had made associated lifestyle changes due to their intolerance (CI/ LSC), self-reported CI who had not made such changes (CI), and normal controls without self-reported CI. Subjects underwent two sessions involving one-minute EEG recordings during exposures to low level chemical odors (a probe for limbic activation). The CI, but not the CI/ LSC, subjects had increased absolute delta power after the chemical exposures during the second, but not the first, session. The findings support the neural sensitization hypothesis for intolerance to low levels of environmental chemicals in vulnerable individuals. As in human studies of stimulant drug sensitization, those with the strongest past history with sensitizing agents may not show-term sensitization to low level exposures in the laboratory.",
keywords = "Chemical intolerance, Delta, Limbic, Sensitization, Spectral power, Temporal-parietal",
author = "Bell, {Iris R.} and Szarek, {Michael J.} and Dicenso, {Dina R.} and Baldwin, {Carol M.} and Schwartz, {Gary E.} and Bootzin, {Richard R.}",
note = "Funding Information: Previous studies indicate that low level chemical intolerance (CI) is a symptom of several different controversial conditions with neuropsychiatric features, e.g., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and {"}Persian Gulf Syndrome{"}. Prior studies suggest that limbic and/or mesolimbic sensitization may contribute to development of CI. The purpose of this report was to document the waking electroencephalographic (EEG) patterns of individuals with CI during chemical exposures presented over repeated sessions. Three groups of adult subjects who were recruited from the community participated in the study: self-reported C1 who had made associated lifestyle changes due to their intolerance (Cl,' LSC), self-reported CI who had not made such changes (CI), and normal controls without self-reported CI. Subjects underwent two sessions involving one-minute EEG recordings during exposures to low level chemical odors (a probe for limbic activation). The CI, but not the CI LSC, subjects had increased absolute delta power after the chemical exposures during the second, but not the first, session. The findings support the neural sensitization hypothesis for intolerance to low levels of environmental chemicals in vulnerable individuals. As in human *This work was completed at the Sleep Research Laboratory, Department of Psychology. The University of Arizona, Tucson, AZ 85721. This study was supported by a grant from the Wallacc Genetic Foundation (PI: IRB). 'Address for correspondence: Department of Psychiatry, Tucson VA Medical Center, 3601 S. 6th Avenue MS 4-1 16A, Tucson, AZ 85723. Tel.: 520/792-1450 x5127: Fax: 5201629-4632; e-mail: IBELL(u U.ARIZONA.EDU",
year = "1999",
doi = "10.3109/00207459908994302",
language = "English (US)",
volume = "97",
pages = "41--59",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "1-2",
}