Patterns of transitional mutation biases within and among mammalian genomes

Michael S. Rosenberg, Sankar Subramanian, Sudhir Kumar

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Significant transition/transversion mutation bias is a well-appreciated aspect of mammalian nuclear genomes; however, patterns of bias among genes within a genome and among species remain largely uncharacterized. Understanding these patterns is important for understanding similarities and differences in mutational patterns among genomes and genomic regions. Therefore, we have conducted an analysis of 7,587 pairs of sequences of 4,347 mammalian protein-coding genes from seven species (human, mouse, rat, cow, sheep, pig, and macaque) and from the introns of 51 gene pairs and multiple intergenic regions (37 kbp, 52 kbp and 65 kbp) from the human, chimpanzee, and baboon genomes. Our analyses show that genes and regions with widely varying base composition exhibit uniformity of transition mutation rate both within and among mammalian lineages, as long as the transitional mutations caused by CpG hypermutability are excluded. The estimates show no relationship to potential intrachromosomal or interchromosomal effects. This uniformity points to similarity in point mutation processes in genomic regions with substantially different GC-content biases.

Original languageEnglish (US)
Pages (from-to)988-993
Number of pages6
JournalMolecular biology and evolution
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Mammalian genomes
  • Substitution patterns
  • Transition/transversion bias

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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