TY - JOUR
T1 - Patterns of neurotrophin protein levels in male and female fischer 344 rats from adulthood to senescence
T2 - How young is "young" and how old is "old"?
AU - Bimonte-Nelson, Heather
AU - Granholm, Ann Charlotte E
AU - Nelson, Matthew E.
AU - Moore, Alfred B.
PY - 2008/1
Y1 - 2008/1
N2 - The current study assessed neurotrophin protein levels in male and female rat brain tissues at four different ages ranging from postpuberty to senescence. In both sexes nerve growth factor (NGF) increased, and brain-derived neurotrophic factor (BDNF) decreased, from 4 to 24 months of age. Using a slightly older age for the young group, or a slightly younger age for the aged group, had profound effects on whether age effects were realized. There were no sex differences in the pattern of change in neurotrophin levels across age, and neurotrophin levels did not correlate with estrogen levels in females or estrogen or testosterone levels in males. The current findings suggest that profound changes in neurotrophin protein levels can occur within only a few months time, and that these changes influence whether age-related neurotrophin alterations are realized.
AB - The current study assessed neurotrophin protein levels in male and female rat brain tissues at four different ages ranging from postpuberty to senescence. In both sexes nerve growth factor (NGF) increased, and brain-derived neurotrophic factor (BDNF) decreased, from 4 to 24 months of age. Using a slightly older age for the young group, or a slightly younger age for the aged group, had profound effects on whether age effects were realized. There were no sex differences in the pattern of change in neurotrophin levels across age, and neurotrophin levels did not correlate with estrogen levels in females or estrogen or testosterone levels in males. The current findings suggest that profound changes in neurotrophin protein levels can occur within only a few months time, and that these changes influence whether age-related neurotrophin alterations are realized.
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U2 - 10.1080/03610730701761908
DO - 10.1080/03610730701761908
M3 - Article
C2 - 18189165
AN - SCOPUS:38149025662
SN - 0361-073X
VL - 34
SP - 13
EP - 26
JO - Experimental Aging Research
JF - Experimental Aging Research
IS - 1
ER -