Pathological trajectory in the Ts65Dn model of Down syndrome

Savannah Tallino, Wendy Winslow, Ramon Velazquez

Research output: Contribution to journalEditorialpeer-review


As the world’s population ages, dementia from Alzheimer’s disease (AD) is projected to increase astronomically; individuals with Down syndrome (DS) are counted among those virtually guaranteed to develop AD pathology and, if they live long enough, AD dementia [1, 2]. DS is characterized by intellectual disability and for decades featured a high incidence of congenital heart abnormalities leading to early mortality. However, recent medical advances drastically improved the life expectancy in DS; more than a quarter of a million people living with DS in the United States are now projected to age long enough to develop AD [2].

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
Issue number2
StatePublished - 2023
Externally publishedYes


  • Down syndrome
  • Ts65Dn
  • amyloid-beta
  • cholinergic

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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