Pathogenic diversity of Escherichia coli and the emergence of 'exotic' islands in the gene stream

Charles M. Dozois, Roy Curtiss

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Escherichia coli is a highly adaptive bacterial species that is both a member of the commensal intestinal flora and a versatile pathogen associated with numerous types of intestinal and systemic infections in humans and other animals. The spectrum of diseases caused by E. coli is due to the acquisition of specific virulence genes harbored on plasmids, bacteriophages, or within distinct DNA segments termed pathogenicity islands (PAIs) that are absent from the genomes of commensal E. coli strains. PAIs are likely to have been transferred horizontally and may have integrated into the E. coli chromosome through bacteriophage or plasmid integration or transposition. The contribution of intergenic inheritance to the adaptation and evolution of E. coli, types of PAIs associated with different groups of pathogenic E. coli and approaches to identify unique sequence islands (USIs), some of which might confer pathogenicity, in E. coli and other bacteria are presented.

Original languageEnglish (US)
Pages (from-to)157-179
Number of pages23
JournalVeterinary Research
Volume30
Issue number2-3
StatePublished - Mar 1999
Externally publishedYes

Fingerprint

Islands
Escherichia coli
pathogenicity islands
Genomic Islands
Genes
genes
bacteriophages
Bacteriophages
Virulence
plasmids
Plasmids
transposition (genetics)
intestinal microorganisms
inheritance (genetics)
virulence
pathogenicity
Chromosomes
Genome
chromosomes
Bacteria

Keywords

  • Adaptation
  • Escherichia coli
  • Horizontal gene transfer
  • Pathogenicity island

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pathogenic diversity of Escherichia coli and the emergence of 'exotic' islands in the gene stream. / Dozois, Charles M.; Curtiss, Roy.

In: Veterinary Research, Vol. 30, No. 2-3, 03.1999, p. 157-179.

Research output: Contribution to journalArticle

Dozois, Charles M. ; Curtiss, Roy. / Pathogenic diversity of Escherichia coli and the emergence of 'exotic' islands in the gene stream. In: Veterinary Research. 1999 ; Vol. 30, No. 2-3. pp. 157-179.
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