Pathogenesis and management of pruritus in cholestatic liver disease

Mohamad H. Imam, Andrea A. Gossard, Emmanouil Sinakos, Keith Lindor

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume27
Issue number7
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Pruritus
Liver Diseases
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Cholestasis
Bile Acids and Salts
Histamine
Opioid Analgesics
Progesterone
lysophosphatidic acid
Intrahepatic Cholestasis of Pregnancy

Keywords

  • Cholestatic
  • Itch
  • Liver
  • Pruritus

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Pathogenesis and management of pruritus in cholestatic liver disease. / Imam, Mohamad H.; Gossard, Andrea A.; Sinakos, Emmanouil; Lindor, Keith.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 27, No. 7, 2012, p. 1150-1158.

Research output: Contribution to journalArticle

Imam, Mohamad H. ; Gossard, Andrea A. ; Sinakos, Emmanouil ; Lindor, Keith. / Pathogenesis and management of pruritus in cholestatic liver disease. In: Journal of Gastroenterology and Hepatology (Australia). 2012 ; Vol. 27, No. 7. pp. 1150-1158.
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