Pathogenesis and management of pruritus in cholestatic liver disease

Mohamad H. Imam, Andrea A. Gossard, Emmanouil Sinakos, Keith D. Lindor

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume27
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Cholestatic
  • Itch
  • Liver
  • Pruritus

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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