Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso; M. Stamelou; C. G. Goetz; W. Poewe; A. E. Lang; D. Weintraub; D. Burn; G. M. Halliday; E. Bezard; S. Przedborski; S. Lehericy; D. J. Brooks; J. C. Rothwell; M. Hallett; M. R. DeLong; C. Marras; C. M. Tanner; G. W. Ross; J. W. Langston; C. Klein; V. Bonifati; J. Jankovic; A. M. Lozano; G. Deuschl; H. Bergman; E. Tolosa; M. Rodriguez-Violante; S. Fahn; R. B. Postuma; D. Berg; K. Marek; D. G. Standaert; D. J. Surmeier; C. W. Olanow; J. H. Kordower; P. Calabresi; A. H.V. Schapira; A. J. Stoessl

doi:10.1002/mds.27115

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso, M. Stamelou, C. G. Goetz, W. Poewe, A. E. Lang, D. Weintraub, D. Burn, G. M. Halliday, E. Bezard, S. Przedborski, S. Lehericy, D. J. Brooks, J. C. Rothwell, M. Hallett, M. R. DeLong, C. Marras, C. M. Tanner, G. W. Ross, J. W. Langston, C. KleinV. Bonifati, J. Jankovic, A. M. Lozano, G. Deuschl, H. Bergman, E. Tolosa, M. Rodriguez-Violante, S. Fahn, R. B. Postuma, D. Berg, K. Marek, D. G. Standaert, D. J. Surmeier, C. W. Olanow, J. H. Kordower, P. Calabresi, A. H.V. Schapira, A. J. Stoessl

Research output: Contribution to journal › Review article › peer-review

520 Scopus citations

Abstract

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

Original language	English (US)
Pages (from-to)	1264-1310
Number of pages	47
Journal	Movement Disorders
Volume	32
Issue number	9
DOIs	https://doi.org/10.1002/mds.27115
State	Published - Sep 2017
Externally published	Yes

Keywords

200 years anniversary
Parkinson's disease
Shaking Palsy

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.27115

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Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D. J., Rothwell, J. C., Hallett, M., DeLong, M. R., Marras, C., Tanner, C. M., Ross, G. W., Langston, J. W., ... Stoessl, A. J. (2017). Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Movement Disorders, 32(9), 1264-1310. https://doi.org/10.1002/mds.27115

Obeso, JA, Stamelou, M, Goetz, CG, Poewe, W, Lang, AE, Weintraub, D, Burn, D, Halliday, GM, Bezard, E, Przedborski, S, Lehericy, S, Brooks, DJ, Rothwell, JC, Hallett, M, DeLong, MR, Marras, C, Tanner, CM, Ross, GW, Langston, JW, Klein, C, Bonifati, V, Jankovic, J, Lozano, AM, Deuschl, G, Bergman, H, Tolosa, E, Rodriguez-Violante, M, Fahn, S, Postuma, RB, Berg, D, Marek, K, Standaert, DG, Surmeier, DJ, Olanow, CW, Kordower, JH, Calabresi, P, Schapira, AHV & Stoessl, AJ 2017, 'Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy', Movement Disorders, vol. 32, no. 9, pp. 1264-1310. https://doi.org/10.1002/mds.27115

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title = "Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy",

abstract = "This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.",

keywords = "200 years anniversary, Parkinson's disease, Shaking Palsy",

author = "Obeso, {J. A.} and M. Stamelou and Goetz, {C. G.} and W. Poewe and Lang, {A. E.} and D. Weintraub and D. Burn and Halliday, {G. M.} and E. Bezard and S. Przedborski and S. Lehericy and Brooks, {D. J.} and Rothwell, {J. C.} and M. Hallett and DeLong, {M. R.} and C. Marras and Tanner, {C. M.} and Ross, {G. W.} and Langston, {J. W.} and C. Klein and V. Bonifati and J. Jankovic and Lozano, {A. M.} and G. Deuschl and H. Bergman and E. Tolosa and M. Rodriguez-Violante and S. Fahn and Postuma, {R. B.} and D. Berg and K. Marek and Standaert, {D. G.} and Surmeier, {D. J.} and Olanow, {C. W.} and Kordower, {J. H.} and P. Calabresi and Schapira, {A. H.V.} and Stoessl, {A. J.}",

note = "Publisher Copyright: {\textcopyright} 2017 International Parkinson and Movement Disorder Society",

year = "2017",

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AU - Stamelou, M.

AU - Goetz, C. G.

AU - Poewe, W.

AU - Lang, A. E.

AU - Weintraub, D.

AU - Burn, D.

AU - Halliday, G. M.

AU - Bezard, E.

AU - Przedborski, S.

AU - Lehericy, S.

AU - Brooks, D. J.

AU - Rothwell, J. C.

AU - Hallett, M.

AU - DeLong, M. R.

AU - Marras, C.

AU - Tanner, C. M.

AU - Ross, G. W.

AU - Langston, J. W.

AU - Klein, C.

AU - Bonifati, V.

AU - Jankovic, J.

AU - Lozano, A. M.

AU - Deuschl, G.

AU - Bergman, H.

AU - Tolosa, E.

AU - Rodriguez-Violante, M.

AU - Fahn, S.

AU - Postuma, R. B.

AU - Berg, D.

AU - Marek, K.

AU - Standaert, D. G.

AU - Surmeier, D. J.

AU - Olanow, C. W.

AU - Kordower, J. H.

AU - Calabresi, P.

AU - Schapira, A. H.V.

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AB - This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

Abstract

Keywords

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