Partially overlapping sensorimotor networks underlie speech praxis and verbal short-term memory: Evidence from apraxia of speech following acute stroke

Gregory Hickok, Corianne Reddy, Rong Chen, Edward H. Herskovits, Sarah Townsley, Argye E. Hillis

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    Abstract

    We tested the hypothesis that motor planning and programming of speech articulation and verbal short-term memory (vSTM) depend on partially overlapping networks of neural regions. We evaluated this proposal by testing 76 individuals with acute ischemic stroke for impairment in motor planning of speech articulation (apraxia of speech, AOS) and vSTM in the first day of stroke, before the opportunity for recovery or reorganization of structure-function relationships. We also evaluated areas of both infarct and low blood flow that might have contributed to AOS or impaired vSTM in each person. We found that AOS was associated with tissue dysfunction in motor-related areas (posterior primary motor cortex, pars opercularis; premotor cortex, insula) and sensory-related areas (primary somatosensory cortex, secondary somatosensory cortex, parietal operculum/auditory cortex); while impaired vSTM was associated with primarily motor-related areas (pars opercularis and pars triangularis, premotor cortex, and primary motor cortex). These results are consistent with the hypothesis, also supported by functional imaging data, that both speech praxis and vSTM rely on partially overlapping networks of brain regions.

    Original languageEnglish (US)
    Article number649
    JournalFrontiers in Human Neuroscience
    Volume8
    Issue numberAUG
    DOIs
    Publication statusPublished - Aug 25 2014

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    Keywords

    • Aphasia
    • Apraxia of speech
    • Language
    • Motor control
    • Short term memory
    • Speech production
    • Stroke

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Neurology
    • Biological Psychiatry
    • Behavioral Neuroscience
    • Neuropsychology and Physiological Psychology

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