TY - JOUR
T1 - Parenteral bisphosphonates for osteoporosis in patients with primary biliary cirrhosis
AU - Treeprasertsuk, Sombat
AU - Silveira, Marina G.
AU - Petz, Janice L.
AU - Lindor, Keith D.
PY - 2011/9
Y1 - 2011/9
N2 - We aimed to describe the effects of parenteral bisphosphonates on bone mineral density (BMD) changes in primary biliary cirrhosis (PBC) patients with osteoporosis. Seventeen PBC patients with osteoporosis diagnosed between 1996 and 2005 were enrolled retrospectively. All patients received one of the following parenteral bisphosphonates: zoledronic acid, pamidronate disodium, or ibandronate sodium. The median (interquartile range) age of patients at osteoporosis diagnosis was 62.2 (56.4-67.9) and 94% were women. After treatment, percent change of lumbar spine bone mineral density (LS-BMD) and proximal femur BMD (PF-BMD) of patients with PBC was 2.9% and 0.4%, respectively. Eight patients (47%) showed a greater LS-BMD and/or PF-BMD with percent change of LS-BMD and PF-BMD of 8.7% and 0.8%, respectively. No serious adverse events were found. In PBC patients with osteoporosis, parenteral bisphosphonates can stabilize BMD for 47% of patients. More prospective studies are needed to evaluate the efficacy of specific parenteral bisphosphonates in patients with PBC and osteoporosis.
AB - We aimed to describe the effects of parenteral bisphosphonates on bone mineral density (BMD) changes in primary biliary cirrhosis (PBC) patients with osteoporosis. Seventeen PBC patients with osteoporosis diagnosed between 1996 and 2005 were enrolled retrospectively. All patients received one of the following parenteral bisphosphonates: zoledronic acid, pamidronate disodium, or ibandronate sodium. The median (interquartile range) age of patients at osteoporosis diagnosis was 62.2 (56.4-67.9) and 94% were women. After treatment, percent change of lumbar spine bone mineral density (LS-BMD) and proximal femur BMD (PF-BMD) of patients with PBC was 2.9% and 0.4%, respectively. Eight patients (47%) showed a greater LS-BMD and/or PF-BMD with percent change of LS-BMD and PF-BMD of 8.7% and 0.8%, respectively. No serious adverse events were found. In PBC patients with osteoporosis, parenteral bisphosphonates can stabilize BMD for 47% of patients. More prospective studies are needed to evaluate the efficacy of specific parenteral bisphosphonates in patients with PBC and osteoporosis.
KW - bone disease
KW - parenteral bisphosphonates
KW - primary biliary cirrhosis
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=80052706885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052706885&partnerID=8YFLogxK
U2 - 10.1097/MJT.0b013e3181d7e1d3
DO - 10.1097/MJT.0b013e3181d7e1d3
M3 - Article
C2 - 20460985
AN - SCOPUS:80052706885
SN - 1075-2765
VL - 18
SP - 375
EP - 381
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
IS - 5
ER -