Parental history and risk of type 2 diabetes in overweight Latino adolescents: A longitudinal analysis

Louise A. Kelly, Christianne J. Lane, Marc J. Weigensberg, Corinna Koebnick, Christian K. Roberts, Jaimie N. Davis, Claudia M. Toledo-Corral, Gabriel Q. Shaibi, Michael I. Goran

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

OBJECTIVE - The purpose of this article was to examine metabolic risk factors for type 2 diabetes in children and adolescents as a function of maternal versus paternal family history of type 2 diabetes and to examine whether differences in these risk factors emerge during adolescent growth. RESEARCH DESIGN AND METHODS - A total of 247 overweight Latino children (baseline age = 11.1 ± 1.7 years) with a parental history of type 2 diabetes were followed annually for 5 years (2.2 ± 1.2 observations/child) with measures of insulin sensitivity, acute insulin response to glucose, and disposition index. Longitudinal linear mixed-effects modeling was used to evaluate the influence of maternal versus paternal family history of type 2 diabetes on changes in diabetes risk factors over age. RESULTS - Insulin sensitivity and the disposition index decreased over age (β = -0.052 and β = -0.033, P < 0 0.01). Acute insulin response to glucose and fasting and 2-h glucose increased (β = 0.019, β = 0.002, and β = 0.003, P < 0.01). Declines in insulin sensitivity were significantly greater in participants whose maternal grandmothers had a history of type 2 diabetes (β = -0.03, P = 0.03). Declines in the disposition index (β = -0.02, P = 0.04) and increases in fasting glucose were significantly influenced by a maternal history of type 2 diabetes (β = 0.60, P < 0.05). CONCLUSIONS - Maternal but not paternal family history for diabetes may have a significant impact on insulin dynamics, becoming more pronounced during growth in overweight Latino adolescents. Further research is clearly warranted.

Original languageEnglish (US)
Pages (from-to)2700-2705
Number of pages6
JournalDiabetes Care
Volume30
Issue number10
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Kelly, L. A., Lane, C. J., Weigensberg, M. J., Koebnick, C., Roberts, C. K., Davis, J. N., Toledo-Corral, C. M., Shaibi, G. Q., & Goran, M. I. (2007). Parental history and risk of type 2 diabetes in overweight Latino adolescents: A longitudinal analysis. Diabetes Care, 30(10), 2700-2705. https://doi.org/10.2337/dc07-0050