Pan-Enterovirus Amplicon-Based High-Throughput Sequencing Detects the Complete Capsid of a EVA71 Genotype C1 Variant via Wastewater-Based Epidemiology in Arizona

Temitope O.C. Faleye, Erin Driver, Devin Bowes, Sangeet Adhikari, Deborah Adams, Arvind Varsani, Rolf U. Halden, Matthew Scotch

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the complete capsid of a genotype C1-like Enterovirus A71 variant recovered from wastewater in a neighborhood in the greater Tempe, Arizona area (Southwest United States) in May 2020 using a pan-enterovirus amplicon-based high-throughput sequencing strategy. The variant seems to have been circulating for over two years, but its sequence has not been documented in that period. As the SARS-CoV-2 pandemic has resulted in changes in health-seeking behavior and overwhelmed pathogen diagnostics, our findings highlight the importance of wastewater-based epidemiology (WBE ) as an early warning system for virus surveillance.

Original languageEnglish (US)
JournalViruses
Volume13
Issue number1
DOIs
StatePublished - Jan 7 2021

Keywords

  • Arizona
  • Enterovirus A
  • human
  • molecular epidemiology
  • poliomyelitis
  • wastewater

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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