Pairwise linkage analysis of 11 loci on human chromosome 4

J. C. Murray, Kenneth Buetow, M. Smith, L. Carlock, A. Chakravarti, R. F. Ferrell, L. Gedamu, C. Gilliam, R. Shiang, C. R. DeHaven

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

Original languageEnglish (US)
Pages (from-to)490-497
Number of pages8
JournalAmerican Journal of Human Genetics
Volume42
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 4
Human Chromosomes
Interleukin-2
Epidermal Growth Factor
Genetic Linkage
Alcohol Dehydrogenase
Restriction Fragment Length Polymorphisms
Genetic Recombination

ASJC Scopus subject areas

  • Genetics

Cite this

Murray, J. C., Buetow, K., Smith, M., Carlock, L., Chakravarti, A., Ferrell, R. F., ... DeHaven, C. R. (1988). Pairwise linkage analysis of 11 loci on human chromosome 4. American Journal of Human Genetics, 42(3), 490-497.

Pairwise linkage analysis of 11 loci on human chromosome 4. / Murray, J. C.; Buetow, Kenneth; Smith, M.; Carlock, L.; Chakravarti, A.; Ferrell, R. F.; Gedamu, L.; Gilliam, C.; Shiang, R.; DeHaven, C. R.

In: American Journal of Human Genetics, Vol. 42, No. 3, 1988, p. 490-497.

Research output: Contribution to journalArticle

Murray, JC, Buetow, K, Smith, M, Carlock, L, Chakravarti, A, Ferrell, RF, Gedamu, L, Gilliam, C, Shiang, R & DeHaven, CR 1988, 'Pairwise linkage analysis of 11 loci on human chromosome 4', American Journal of Human Genetics, vol. 42, no. 3, pp. 490-497.
Murray JC, Buetow K, Smith M, Carlock L, Chakravarti A, Ferrell RF et al. Pairwise linkage analysis of 11 loci on human chromosome 4. American Journal of Human Genetics. 1988;42(3):490-497.
Murray, J. C. ; Buetow, Kenneth ; Smith, M. ; Carlock, L. ; Chakravarti, A. ; Ferrell, R. F. ; Gedamu, L. ; Gilliam, C. ; Shiang, R. ; DeHaven, C. R. / Pairwise linkage analysis of 11 loci on human chromosome 4. In: American Journal of Human Genetics. 1988 ; Vol. 42, No. 3. pp. 490-497.
@article{8041873d70f14a4893449f01a83cba00,
title = "Pairwise linkage analysis of 11 loci on human chromosome 4",
abstract = "New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.",
author = "Murray, {J. C.} and Kenneth Buetow and M. Smith and L. Carlock and A. Chakravarti and Ferrell, {R. F.} and L. Gedamu and C. Gilliam and R. Shiang and DeHaven, {C. R.}",
year = "1988",
language = "English (US)",
volume = "42",
pages = "490--497",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Pairwise linkage analysis of 11 loci on human chromosome 4

AU - Murray, J. C.

AU - Buetow, Kenneth

AU - Smith, M.

AU - Carlock, L.

AU - Chakravarti, A.

AU - Ferrell, R. F.

AU - Gedamu, L.

AU - Gilliam, C.

AU - Shiang, R.

AU - DeHaven, C. R.

PY - 1988

Y1 - 1988

N2 - New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

AB - New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

UR - http://www.scopus.com/inward/record.url?scp=0023921837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023921837&partnerID=8YFLogxK

M3 - Article

C2 - 2894759

AN - SCOPUS:0023921837

VL - 42

SP - 490

EP - 497

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 3

ER -