p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

Susan B. Parker, Gregor Eichele, Pumin Zhang, Jeffery Rawls, Arthur T. Sands, Allan Bradley, Eric N. Olson, J. Wade Harper, Stephen J. Elledge

Research output: Contribution to journalArticle

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Abstract

Terminal differentiation is coupled to withdrawal from the cell cycle. The cyclin-dependent kinase inhibitor (CKI) p21Cip1 is transcriptionally regulated by p53 and can induce growth arrest. CKIs are therefore potential mediators of developmental control of cell proliferation. The expression pattern of mouse p21 correlated with terminal differentiation of multiple cell lineages including skeletal muscle, cartilage, skin, and nasal epithelium in a p53-independent manner. Although the muscle-specific transcription factor MyoD is sufficient to activate p21 expression in 10T1/2 cells, p21 was expressed in myogenic cells of mice lacking the genes encoding MyoD and myogenin, demonstrating that p21 expression does not require these transcription factors. The p21 protein may function during development as an inducible growth inhibitor that contributes to cell cycle exit and differentiation.

Original languageEnglish (US)
Pages (from-to)1024-1027
Number of pages4
JournalScience
Volume267
Issue number5200
StatePublished - Feb 17 1995
Externally publishedYes

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Cell Cycle
Transcription Factors
Myogenin
Muscles
Growth Inhibitors
Cyclin-Dependent Kinases
Nasal Mucosa
Cell Lineage
Cartilage
Cell Differentiation
Skeletal Muscle
Cell Proliferation
Skin
Growth
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Parker, S. B., Eichele, G., Zhang, P., Rawls, J., Sands, A. T., Bradley, A., ... Elledge, S. J. (1995). p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science, 267(5200), 1024-1027.

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. / Parker, Susan B.; Eichele, Gregor; Zhang, Pumin; Rawls, Jeffery; Sands, Arthur T.; Bradley, Allan; Olson, Eric N.; Harper, J. Wade; Elledge, Stephen J.

In: Science, Vol. 267, No. 5200, 17.02.1995, p. 1024-1027.

Research output: Contribution to journalArticle

Parker, SB, Eichele, G, Zhang, P, Rawls, J, Sands, AT, Bradley, A, Olson, EN, Harper, JW & Elledge, SJ 1995, 'p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells', Science, vol. 267, no. 5200, pp. 1024-1027.
Parker SB, Eichele G, Zhang P, Rawls J, Sands AT, Bradley A et al. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science. 1995 Feb 17;267(5200):1024-1027.
Parker, Susan B. ; Eichele, Gregor ; Zhang, Pumin ; Rawls, Jeffery ; Sands, Arthur T. ; Bradley, Allan ; Olson, Eric N. ; Harper, J. Wade ; Elledge, Stephen J. / p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. In: Science. 1995 ; Vol. 267, No. 5200. pp. 1024-1027.
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AU - Sands, Arthur T.

AU - Bradley, Allan

AU - Olson, Eric N.

AU - Harper, J. Wade

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