Overview of the avian immune system

J. M. Sharma

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The avian immune system operates on the same general principles as the mammalian immune system. Antigenic stimulation initiates an immune response that involves cellular cooperation most notably between macrophages, B lymphocytes and T lymphocytes. Macrophages process the antigen and present the antigen to the lymphocytes. B lymphocytes, the principal cells that mediate humoral immunity, transform into plasma cells and produce antibodies. T lymphocytes, most important for cellular immunity, differentiate into functionally diverse subpopulations. The subpopulations of avian T cells have been identified with monoclonal reagents and appear to be similar to those of mammalian T cells. Lymphokines, the soluble products secreted by immune cells, mediate the functions of these cells. Studies on avian lymphokines have lagged behind those on mammalian lymphokines because the genes coding for avian lymphokines have not been cloned. The avian lymphokines studied thus far appear to function along the same lines as the mammalian lymphokines. The immune response in birds is highly regulated and breakdown in regulation often results in immunodepression.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume30
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

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lymphokines
Lymphokines
immune system
Immune System
T-lymphocytes
T-Lymphocytes
Cellular Immunity
cell-mediated immunity
B-lymphocytes
macrophages
B-Lymphocytes
Macrophages
antigens
Antigens
plasma cells
cells
Humoral Immunity
Plasma Cells
humoral immunity
Immunosuppression

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Overview of the avian immune system. / Sharma, J. M.

In: Veterinary Immunology and Immunopathology, Vol. 30, No. 1, 1991, p. 13-17.

Research output: Contribution to journalArticle

Sharma, J. M. / Overview of the avian immune system. In: Veterinary Immunology and Immunopathology. 1991 ; Vol. 30, No. 1. pp. 13-17.
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