Overcoming cytoplasmic incompatibility in Drosophila

T. L. Karr, W. Yang, M. E. Feder

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The endocellular microbe Wolbachia pipientis infects a wide variety of invertebrate species, in which its presence is closely linked to a form of reproductive failure termed cytoplasmic incompatibility (CI). CI renders infected males unable to father offspring when mated to uninfected females. Because CI can dramatically affect fitness in natural populations, mechanisms that abate CI can have equally large impacts on fitness. We have discovered that repeated copulation by Wolbachia-infected male Drosophila simulans significantly diminishes CI. Repeated copulation does not prevent Wolbachia from populating developing spermatids, but may reduce the time during spermatogenesis when Wolbachia can express CI. This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalProceedings of the Royal Society B: Biological Sciences
Volume265
Issue number1394
DOIs
StatePublished - Mar 7 1998
Externally publishedYes

Fingerprint

cytoplasmic incompatibility
Pest control
Wolbachia
Restoration
Drosophila
Copulation
copulation
Biological Pest Control
fitness
Wolbachia pipientis
Spermatids
Drosophila simulans
Spermatogenesis
Invertebrates
Fathers
spermatids
fathers
Fertility
spermatogenesis
pest control

Keywords

  • Cytoplasmic incompatibility
  • Drosophila
  • Fertilization
  • Sperm
  • Wolbachia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Overcoming cytoplasmic incompatibility in Drosophila. / Karr, T. L.; Yang, W.; Feder, M. E.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 265, No. 1394, 07.03.1998, p. 391-395.

Research output: Contribution to journalArticle

@article{e1a984410dc84e3ba467ba41f3db8836,
title = "Overcoming cytoplasmic incompatibility in Drosophila",
abstract = "The endocellular microbe Wolbachia pipientis infects a wide variety of invertebrate species, in which its presence is closely linked to a form of reproductive failure termed cytoplasmic incompatibility (CI). CI renders infected males unable to father offspring when mated to uninfected females. Because CI can dramatically affect fitness in natural populations, mechanisms that abate CI can have equally large impacts on fitness. We have discovered that repeated copulation by Wolbachia-infected male Drosophila simulans significantly diminishes CI. Repeated copulation does not prevent Wolbachia from populating developing spermatids, but may reduce the time during spermatogenesis when Wolbachia can express CI. This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control.",
keywords = "Cytoplasmic incompatibility, Drosophila, Fertilization, Sperm, Wolbachia",
author = "Karr, {T. L.} and W. Yang and Feder, {M. E.}",
year = "1998",
month = "3",
day = "7",
doi = "10.1098/rspb.1998.0307",
language = "English (US)",
volume = "265",
pages = "391--395",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0800-4622",
publisher = "Royal Society of London",
number = "1394",

}

TY - JOUR

T1 - Overcoming cytoplasmic incompatibility in Drosophila

AU - Karr, T. L.

AU - Yang, W.

AU - Feder, M. E.

PY - 1998/3/7

Y1 - 1998/3/7

N2 - The endocellular microbe Wolbachia pipientis infects a wide variety of invertebrate species, in which its presence is closely linked to a form of reproductive failure termed cytoplasmic incompatibility (CI). CI renders infected males unable to father offspring when mated to uninfected females. Because CI can dramatically affect fitness in natural populations, mechanisms that abate CI can have equally large impacts on fitness. We have discovered that repeated copulation by Wolbachia-infected male Drosophila simulans significantly diminishes CI. Repeated copulation does not prevent Wolbachia from populating developing spermatids, but may reduce the time during spermatogenesis when Wolbachia can express CI. This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control.

AB - The endocellular microbe Wolbachia pipientis infects a wide variety of invertebrate species, in which its presence is closely linked to a form of reproductive failure termed cytoplasmic incompatibility (CI). CI renders infected males unable to father offspring when mated to uninfected females. Because CI can dramatically affect fitness in natural populations, mechanisms that abate CI can have equally large impacts on fitness. We have discovered that repeated copulation by Wolbachia-infected male Drosophila simulans significantly diminishes CI. Repeated copulation does not prevent Wolbachia from populating developing spermatids, but may reduce the time during spermatogenesis when Wolbachia can express CI. This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control.

KW - Cytoplasmic incompatibility

KW - Drosophila

KW - Fertilization

KW - Sperm

KW - Wolbachia

UR - http://www.scopus.com/inward/record.url?scp=0032492388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032492388&partnerID=8YFLogxK

U2 - 10.1098/rspb.1998.0307

DO - 10.1098/rspb.1998.0307

M3 - Article

C2 - 9523438

AN - SCOPUS:0032492388

VL - 265

SP - 391

EP - 395

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1394

ER -