Abstract

Detection and sizing of metal-containing engineered nanoparticles (ENPs) was achieved at concentrations predicted for environmental samples (part-per trillion levels) using single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). Silver nanowires, titanium dioxide and cerium oxide nanoparticles were found to be detectable by this technique, while zinc oxide dissolved too quickly for analysis at these concentrations. In addition to the potential dissolution of particles, other considerations affecting ENP analysis include: instrumental background, mass interferences, percent metal in a nanoparticle, and isotopic abundance of the analyte element. Sizing of these metal-containing nanoparticles was done by correlating ICP-MS response (pulses) from ENPs entering the plasma to mass of metal in dissolved standards. The resulting particle size distributions compared well with results from sedimentation field-flow fractionation. Coincidence in ENP pulses may be difficult to detect in the broad size distributions that arise from polydisperse samples. Comparison of data obtained by combination of multiple analyses of dilute solutions to single analyses of higher concentration allowed discrimination between coincidence and polydispersity. The ratio of ENP pulse detections to the total number of readings during analysis was optimized at 2.5% or less to minimize coincident pulses while still allowing definition of a size distribution.

Original languageEnglish (US)
Pages (from-to)1093-1100
Number of pages8
JournalJournal of Analytical Atomic Spectrometry
Volume27
Issue number7
DOIs
StatePublished - Jul 2012

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Inductively coupled plasma mass spectrometry
Metals
Nanoparticles
Zinc Oxide
Polydispersity
Fractionation
Silver
Sedimentation
Particle size analysis
Nanowires
Flow fields
Dissolution
Plasmas

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Overcoming challenges in analysis of polydisperse metal-containing nanoparticles by single particle inductively coupled plasma mass spectrometry. / Reed, Robert B.; Higgins, Christopher P.; Westerhoff, Paul; Tadjiki, Soheyl; Ranville, James F.

In: Journal of Analytical Atomic Spectrometry, Vol. 27, No. 7, 07.2012, p. 1093-1100.

Research output: Contribution to journalArticle

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