Overcoming barriers to long-term graft survival

Bruce Kaplan

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations


    Although short-term kidney graft survival has improved in recent years, the focus has shifted to the challenge of improving long-term graft survival. Acute rejection, chronic allograft nephropathy, and cardiovascular disease are associated with graft loss and patient death. Reducing the potential for such posttransplantation complications may improve long-term graft survival. In addition, gaining a better understanding of the role that various immunosuppressive therapies have in decreasing the risk for graft injury will help clinicians make better-informed decisions about appropriate treatment regimens for individual kidney transplant recipients.

    Original languageEnglish (US)
    Pages (from-to)S52-S64
    JournalAmerican Journal of Kidney Diseases
    Issue number4 SUPPL. 2
    StatePublished - Apr 2006


    • Acute rejection
    • Chronic allograft nephropathy (CAN)
    • Cyclosporine (CsA)
    • Graft survival
    • Immunosuppression
    • Kidney transplant
    • Mycophenolate mofetil (MMF)
    • Renal function
    • Sirolimus (SRL)
    • Tacrolimus (TAC)

    ASJC Scopus subject areas

    • Nephrology


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