O2-sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models

Scott C. Beeman, Ying Bo Shui, Carlos J. Perez-Torres, John A. Engelbach, Joseph J.H. Ackerman, Joel R. Garbow

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Purpose The goal of this study was to quantify the relationship between the 1H longitudinal relaxation rate constant, R1, and oxygen (O2) concentration (relaxivity, r1) in tissue and to quantify O2-driven changes in R1 (ΔR1) during a breathing gas challenge in normal brain, radiation-induced lesions, and tumor lesions. Methods R1 data were collected in control-state mice (n = 4) during three different breathing gas (and thus tissue O2) conditions. In parallel experiments, pO2 was measured in the thalamus of control-state mice (n = 4) under the same breathing gas conditions using an O2-sensitive microprobe. The relaxivity of tissue O2 was calculated using the R1 and pO2 data. R1 data were collected in control-state (n = 4) mice, a glioma model (n = 7), and a radiation necrosis model (n = 6) during two breathing gas (thus tissue O2) conditions. R1 and ΔR1 were calculated for each cohort. Results O2 r1 in the brain was 9 × 10-4 ± 3 × 10-4 mm Hg-1· s-1 at 4.7T. R1 and ΔR1 measurements distinguished radiation necrosis from tumor (P< 0.03 and P< 0.01, respectively). Conclusion The relaxivity of O2 in the brain is determined. R1 and ΔR1 measurements differentiate tumor lesions from radiation necrosis lesions in the mouse models. These pathologies are difficult to distinguish by traditional imaging techniques; O2-driven changes in R1 holds promise in this regard.

Original languageEnglish (US)
Pages (from-to)2442-2447
Number of pages6
JournalMagnetic Resonance in Medicine
Volume75
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • T relaxometry
  • radiation necrosis
  • tissue oxygenation
  • tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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