Origins of correlated spiking in the mammalian olfactory bulb

Richard Gerkin, Shreejoy J. Tripathy, Nathaniel N. Urban

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mitral/tufted (M/T) cells of the main olfactory bulb transmit odorant information to higher brain structures. The relative timing of action potentials across M/T cells has been proposed to encode this information and to be critical for the activation of downstream neurons. Using ensemble recordings from the mouse olfactory bulb in vivo, we measured how correlations between cells are shaped by stimulus (odor) identity, common respiratory drive, and other cells' activity. The shared respiration cycle is the largest source of correlated firing, but even after accounting for all observable factors a residual positive noise correlation was observed. Noise correlation was maximal on a ~100-ms timescale and was seen only in cells separated by <200 μm. This correlation is explained primarily by common activity in groups of nearby cells. Thus, M/T-cell correlation principally reflects respiratory modulation and sparse, local network connectivity, with odor identity accounting for a minor component.

Original languageEnglish (US)
Pages (from-to)17083-17088
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number42
DOIs
StatePublished - Oct 15 2013

Fingerprint

Olfactory Bulb
Noise
Action Potentials
Respiration
Neurons
Brain
Odorants

Keywords

  • Olfaction
  • Sensory
  • Statistics
  • Synchrony

ASJC Scopus subject areas

  • General

Cite this

Origins of correlated spiking in the mammalian olfactory bulb. / Gerkin, Richard; Tripathy, Shreejoy J.; Urban, Nathaniel N.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 42, 15.10.2013, p. 17083-17088.

Research output: Contribution to journalArticle

@article{8e289a0eb2c146a1a4f3eab19998ce8e,
title = "Origins of correlated spiking in the mammalian olfactory bulb",
abstract = "Mitral/tufted (M/T) cells of the main olfactory bulb transmit odorant information to higher brain structures. The relative timing of action potentials across M/T cells has been proposed to encode this information and to be critical for the activation of downstream neurons. Using ensemble recordings from the mouse olfactory bulb in vivo, we measured how correlations between cells are shaped by stimulus (odor) identity, common respiratory drive, and other cells' activity. The shared respiration cycle is the largest source of correlated firing, but even after accounting for all observable factors a residual positive noise correlation was observed. Noise correlation was maximal on a ~100-ms timescale and was seen only in cells separated by <200 μm. This correlation is explained primarily by common activity in groups of nearby cells. Thus, M/T-cell correlation principally reflects respiratory modulation and sparse, local network connectivity, with odor identity accounting for a minor component.",
keywords = "Olfaction, Sensory, Statistics, Synchrony",
author = "Richard Gerkin and Tripathy, {Shreejoy J.} and Urban, {Nathaniel N.}",
year = "2013",
month = "10",
day = "15",
doi = "10.1073/pnas.1303830110",
language = "English (US)",
volume = "110",
pages = "17083--17088",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "42",

}

TY - JOUR

T1 - Origins of correlated spiking in the mammalian olfactory bulb

AU - Gerkin, Richard

AU - Tripathy, Shreejoy J.

AU - Urban, Nathaniel N.

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Mitral/tufted (M/T) cells of the main olfactory bulb transmit odorant information to higher brain structures. The relative timing of action potentials across M/T cells has been proposed to encode this information and to be critical for the activation of downstream neurons. Using ensemble recordings from the mouse olfactory bulb in vivo, we measured how correlations between cells are shaped by stimulus (odor) identity, common respiratory drive, and other cells' activity. The shared respiration cycle is the largest source of correlated firing, but even after accounting for all observable factors a residual positive noise correlation was observed. Noise correlation was maximal on a ~100-ms timescale and was seen only in cells separated by <200 μm. This correlation is explained primarily by common activity in groups of nearby cells. Thus, M/T-cell correlation principally reflects respiratory modulation and sparse, local network connectivity, with odor identity accounting for a minor component.

AB - Mitral/tufted (M/T) cells of the main olfactory bulb transmit odorant information to higher brain structures. The relative timing of action potentials across M/T cells has been proposed to encode this information and to be critical for the activation of downstream neurons. Using ensemble recordings from the mouse olfactory bulb in vivo, we measured how correlations between cells are shaped by stimulus (odor) identity, common respiratory drive, and other cells' activity. The shared respiration cycle is the largest source of correlated firing, but even after accounting for all observable factors a residual positive noise correlation was observed. Noise correlation was maximal on a ~100-ms timescale and was seen only in cells separated by <200 μm. This correlation is explained primarily by common activity in groups of nearby cells. Thus, M/T-cell correlation principally reflects respiratory modulation and sparse, local network connectivity, with odor identity accounting for a minor component.

KW - Olfaction

KW - Sensory

KW - Statistics

KW - Synchrony

UR - http://www.scopus.com/inward/record.url?scp=84885780556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885780556&partnerID=8YFLogxK

U2 - 10.1073/pnas.1303830110

DO - 10.1073/pnas.1303830110

M3 - Article

C2 - 24082089

AN - SCOPUS:84885780556

VL - 110

SP - 17083

EP - 17088

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 42

ER -